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Query: LIFR

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LIFR 0 1.061 -0.160 0.460

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LIFR Ubiquitylation K886 0.112 0.489 _ALQFQK(gl)SVCEGSSALK_

Background Information for LIFR:


Pubmed-LIFR »
Uniprot-LIFR »
Biogrid-LIFR »
ProteomicsDB-LIFR »

Tumorportal-LIFR »
COSMIC-LIFR »
GenomeRNAi-LIFR »
Genecards-LIFR


Protein-protein Interactions for LIFR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLAMF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LIFR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Fibronectin_type3 IPR003961 0.19


Protein complexes (CORUM database) featuring LIFR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5582 LIFR-LIF-gp130 complex Database 0.04
Category members Corum 5579 CNTF-CNTFR-gp130-LIFR complex Database 0


Categories featuring LIFR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0004924 oncostatin-M receptor activity Database 0.17
Category members GO Category GO:0038165 oncostatin-M-mediated signaling pathway Database 0.17
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members GO Category GO:0004923 leukemia inhibitory factor receptor activity Database 0.04
Category members GO Category GO:0004897 ciliary neurotrophic factor receptor activity Database 0
Category members GO Category GO:0005127 ciliary neurotrophic factor receptor binding Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0019838 growth factor binding Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0048861 leukemia inhibitory factor signaling pathway Database 0
Category members GO Category GO:0070120 ciliary neurotrophic factor-mediated signaling pathway Database 0


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