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Query: KTN1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KTN1 1 4.904 0.800 -1.010 0.287 0.430

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KTN1 Phosphorylation S75 1.178 0.666 _KEIQNGNLHES(ph)DSESVPR_
KTN1 Phosphorylation S242 0.602 _TENVFVDEPLIHATTYIPLMDNADS(ph)SPVVDKR_
KTN1 Phosphorylation S243 0.536 _TENVFVDEPLIHATTYIPLMDNADSS(ph)PVVDK_
KTN1 Phosphorylation S1313 0.446 0.503 _AAGDTTVIENSDVS(ph)PETESSEK_
KTN1 Ubiquitylation K783 0.348 _EVQDLK(gl)AK_
KTN1 Ubiquitylation K777 -0.423 -0.237 _TENSSLTK(gl)EVQDLK_
KTN1 Phosphorylation T153 -0.616 -1.089 _VEPVPVTKQPT(ph)PPSEAAASK_
KTN1 Ubiquitylation K256 0.681 _EVIDLLK(gl)PDQVEGIQK_
KTN1 Ubiquitylation K443 0.893 _DAVSNTTNQLESK(gl)QSAELNK_
KTN1 Ubiquitylation K543 1.995 _LTDTLVSK(gl)QQLEQR_
KTN1 Ubiquitylation K743 -0.534 _CIQEKDEK(gl)LK_
KTN1 Ubiquitylation K785 -0.101 _EVQDLKAK(gl)_
KTN1 Ubiquitylation K842 0.819 _ALK(gl)EEIGNVQLEK_
KTN1 Ubiquitylation K1173 0.578 _VKVDESHK(gl)TIK_

Background Information for KTN1:


Pubmed-KTN1 »
Uniprot-KTN1 »
Biogrid-KTN1 »
ProteomicsDB-KTN1 »

Tumorportal-KTN1 »
COSMIC-KTN1 »
GenomeRNAi-KTN1 »
Genecards-KTN1


Protein-protein Interactions for KTN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP6AP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait EEF1A1;EEF1A1P5 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PKN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB7A Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED2 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAM32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C17orf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAPN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DTNBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM134C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM167A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IPPK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPAR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDEL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RTN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPC25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPPL2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YIPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KTN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Rib_rcpt_KP IPR007794 0


Protein complexes (CORUM database) featuring KTN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5269 TNF-alpha/NF-kappa B signaling complex 8 Database 1.36


Categories featuring KTN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0007018 microtubule-based movement Database 0.75
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0003674 molecular_function Database 0.08
Category members GO Category GO:0019894 kinesin binding Database 0.02
Category members GO Category GO:0030176 integral to endoplasmic reticulum membrane Database 0


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