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Query: KIF5B

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KIF5B 0 2.208 -0.940 1.450
KIF5B 0 2.208 -0.940 1.450 -0.312
KIF5B 0 2.208 -0.940 1.450 0.018 0.333 0.082

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KIF5B Ubiquitylation K10 0.306 0.853 _(ac)ADLAECNIK(gl)VMCR_
KIF5B Ubiquitylation K656 0.402 0.839 _SLTEYLQNVEQK(gl)KR_
KIF5B Ubiquitylation K657 0.839 _SLTEYLQNVEQK(gl)KR_
KIF5B Ubiquitylation K222 -0.686 -0.137 _QENTQTEQK(gl)LSGK_
KIF5B Phosphorylation S933 -0.617 _PIRPGQHPAAS(ph)PTHPSAIR_
KIF5B Ubiquitylation K256 0.392 _TGAEGAVLDEAKNINK(gl)_
KIF5B Ubiquitylation K420 -0.933 _RK(gl)CEEEIAK_

Background Information for KIF5B:


Pubmed-KIF5B »
Uniprot-KIF5B »
Biogrid-KIF5B »
ProteomicsDB-KIF5B »

Tumorportal-KIF5B »
COSMIC-KIF5B »
GenomeRNAi-KIF5B »
Genecards-KIF5B


Protein-protein Interactions for KIF5B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIF5B Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait L1TD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AZIN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC101 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COG6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DTNBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HOMER1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KPTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAP7D2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUP43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KIF5B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Kinesin_motor_dom IPR001752 0


Protein complexes (CORUM database) featuring KIF5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5401 PLEKHM2-KIF5B complex Database 0


Categories featuring KIF5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0007018 microtubule-based movement Database 0.75
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0003777 microtubule motor activity Database 0.49
Category members GO Category GO:0043268 positive regulation of potassium ion transport Database 0.44
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_1314 REACTOME_KINESINS 0 0.32
Category members Pathway Pathway_562 PID_NCADHERIN_PATHWAY 0 0.29
Category members GO Category GO:0005871 kinesin complex Database 0.27
Category members GO Category GO:0043227 membrane-bounded organelle Database 0.25
Category members GO Category GO:0047496 vesicle transport along microtubule Database 0.19
Category members GO Category GO:0035617 stress granule disassembly Database 0.15
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0035253 ciliary rootlet Database 0.03
Category members GO Category GO:0031982 vesicle Database 0.01
Category members GO Category GO:0042391 regulation of membrane potential Database 0
Category members Pathway Pathway_1256 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING 0 0
Category members GO Category GO:0007028 cytoplasm organization Database 0


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