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Query: KIF2C

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KIF2C 0 -1.374 -0.750 0.150 -1.129 -0.459 0.458 -0.570 -0.151

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KIF2C Ubiquitylation K524 0.780 -0.116 _SLLALK(gl)ECIR_
KIF2C Ubiquitylation K90 0.245 _DNLPLQENVTIQK(gl)QK_
KIF2C Ubiquitylation K92 0.245 _DNLPLQENVTIQK(gl)QK_
KIF2C Ubiquitylation K99 -0.690 _SVNSK(gl)IPAPK_
KIF2C Phosphorylation S187 -0.968 _GSSSANPVNS(ph)VR_
KIF2C Ubiquitylation K196 0.896 _SCLVK(gl)EVEK_
KIF2C Ubiquitylation K365 1.333 _THTMGGDLSGK(gl)AQNASK_
KIF2C Ubiquitylation K702 1.411 _DVIK(gl)ALR_

Background Information for KIF2C:


Pubmed-KIF2C »
Uniprot-KIF2C »
Biogrid-KIF2C »
ProteomicsDB-KIF2C »

Tumorportal-KIF2C »
COSMIC-KIF2C »
GenomeRNAi-KIF2C »
Genecards-KIF2C


Protein-protein Interactions for KIF2C
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIF2A Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF2C Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SGOL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC101 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIF2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PAPLN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RELL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCP10L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TYW3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDYHV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KIF2C
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Kinesin_motor_dom IPR001752 0


Protein complexes (CORUM database) featuring KIF2C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring KIF2C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0007018 microtubule-based movement Database 0.75
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0003777 microtubule motor activity Database 0.49
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0051010 microtubule plus-end binding Database 0.47
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_1314 REACTOME_KINESINS 0 0.32
Category members GO Category GO:0000777 condensed chromosome kinetochore Database 0.32
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0005871 kinesin complex Database 0.27
Category members GO Category GO:0019237 centromeric DNA binding Database 0.23
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0005881 cytoplasmic microtubule Database 0.04
Category members GO Category GO:0007019 microtubule depolymerization Database 0
Category members GO Category GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity Database 0
Category members GO Category GO:0035371 microtubule plus-end Database 0
Category members GO Category GO:0051983 regulation of chromosome segregation Database 0


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