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Query: ITM2B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITM2B 0 -0.817 1.680 -1.240

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITM2B Ubiquitylation K13 -0.593 -0.224 _VKVTFNSALAQK(gl)EAK_
ITM2B Ubiquitylation K3 -1.978 _VK(gl)VTFNSALAQK_
ITM2B Ubiquitylation K16 -1.083 _VTFNSALAQKEAK(gl)_

Background Information for ITM2B:


Pubmed-ITM2B »
Uniprot-ITM2B »
Biogrid-ITM2B »
ProteomicsDB-ITM2B »

Tumorportal-ITM2B »
COSMIC-ITM2B »
GenomeRNAi-ITM2B »
Genecards-ITM2B


Protein-protein Interactions for ITM2B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIF18A Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SHOC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FCGRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ITM2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITM2B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BRICHOS_dom IPR007084 0.13


Protein complexes (CORUM database) featuring ITM2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ITM2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_920 REACTOME_AMYLOIDS 0 0.68
Category members GO Category GO:0030660 Golgi-associated vesicle membrane Database 0.44
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0001540 beta-amyloid binding Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0031301 integral to organelle membrane Database 0
Category members GO Category GO:0042985 negative regulation of amyloid precursor protein biosynthetic process Database 0


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