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Query: INTS3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
INTS3 2 2.395 -0.640 1.360 -1.826 2.341 2.591 -0.862

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
INTS3 Phosphorylation S537 -0.010 _IEEPVSMEMDNHMSDKDESCYDNAEAAFS(ph)DDEEDLNSK_
INTS3 Ubiquitylation K852 -0.589 -0.610 _EK(gl)PSEEMVK_
INTS3 Ubiquitylation K898 -0.696 _SLLIK(gl)NNSLPR_

Background Information for INTS3:


Pubmed-INTS3 »
Uniprot-INTS3 »
Biogrid-INTS3 »
ProteomicsDB-INTS3 »

Tumorportal-INTS3 »
COSMIC-INTS3 »
GenomeRNAi-INTS3 »
Genecards-INTS3


Protein-protein Interactions for INTS3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NABP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NABP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait SMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COMTD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INTS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNKD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST6GAL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in INTS3
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring INTS3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1155 Integrator-RNAPII complex Database 5.97
Category members Corum 1153 Integrator complex Database 4.67


Categories featuring INTS3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0032039 integrator complex Database 4.79
Category members GO Category GO:0016180 snRNA processing Database 4.67
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0007093 mitotic cell cycle checkpoint Database 0.27
Category members GO Category GO:0070876 SOSS complex Database 0.05


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