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Query: HSPA4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSPA4 2 9.470 -0.080 0.630 1.166 -0.364
HSPA4 2 9.470 -0.080 0.630 0.518 1.282 -0.078

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSPA4 Ubiquitylation K68 2.744 _NTVQGFK(gl)R_
HSPA4 Phosphorylation S647 0.741 1.114 _FVSEDDRNS(ph)FTLK_
HSPA4 Ubiquitylation K477 -0.698 0.730 _VTPQSDGSSSK(gl)VK_
HSPA4 Ubiquitylation K126 0.347 0.484 _LK(gl)ETAESVLK_
HSPA4 Ubiquitylation K388 0.013 0.181 _GCALQCAILSPAFK(gl)VR_
HSPA4 Ubiquitylation K272 0.617 0.172 _LSQECEK(gl)LKK_
HSPA4 Ubiquitylation K351 -0.272 0.089 _IPAVK(gl)EK_
HSPA4 Ubiquitylation K686 0.085 -0.037 _NLGQPIK(gl)IR_
HSPA4 Ubiquitylation K679 0.015 -0.069 _LAELK(gl)NLGQPIK_
HSPA4 Ubiquitylation K568 -0.150 -0.894 _MDQPPQAK(gl)K_
HSPA4 Ubiquitylation K194 -0.781 -1.204 _QDLPALEEK(gl)PR_
HSPA4 Phosphorylation S76 1.705 _AFS(ph)DPFVEAEK_
HSPA4 Ubiquitylation K329 0.204 _SVLEQTK(gl)LK_
HSPA4 Ubiquitylation K356 0.753 _ISK(gl)FFGK_
HSPA4 Ubiquitylation K479 -0.593 _VTPQSDGSSSKVK(gl)_
HSPA4 Ubiquitylation K612 -0.530 _MIMQDKLEK(gl)_
HSPA4 Ubiquitylation K631 0.051 _DK(gl)LSGEYEK_
HSPA4 Ubiquitylation K674 0.564 _QVYVDK(gl)LAELK_
HSPA4 Ubiquitylation K736 -0.113 _VEK(gl)STNEAMEWMNNK_
HSPA4 Ubiquitylation K754 -0.656 _LNLQNK(gl)QSLTMDPVVK_

Background Information for HSPA4:


Pubmed-HSPA4 »
Uniprot-HSPA4 »
Biogrid-HSPA4 »
ProteomicsDB-HSPA4 »

Tumorportal-HSPA4 »
COSMIC-HSPA4 »
GenomeRNAi-HSPA4 »
Genecards-HSPA4


Protein-protein Interactions for HSPA4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait MBOAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SART3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNJ10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait METTL21A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC27A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCAP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRMT12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTC9B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSPA4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HSP70_C IPR029048 0.66
Category members HSP70_peptide-bd IPR029047 0.55
Category members MreB_Mrl IPR004753 0.4
Category members Hsp_70_fam IPR013126 0.4


Protein complexes (CORUM database) featuring HSPA4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5199 Kinase maturation complex 1 Database 3.38
Category members Corum 2721 HCF-1 complex Database 2.08
Category members Corum 3135 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.58
Category members Corum 1729 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.02
Category members Corum 5386 MLL1-WDR5 complex Database 0.31
Category members Corum 5423 HSP70-BAG5-PARK2 complex Database 0


Categories featuring HSPA4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0006986 response to unfolded protein Database 0.62
Category members GO Category GO:0045040 protein import into mitochondrial outer membrane Database 0.54
Category members GO Category GO:0051131 chaperone-mediated protein complex assembly Database 0.24
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0000902 cell morphogenesis Database 0


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