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Query: HSD17B7

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSD17B7 0 1.245 -0.130 0.330

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSD17B7 Ubiquitylation K321 -0.534 0.412 _LLELEK(gl)HIR_
HSD17B7 Ubiquitylation K176 0.504 0.368 _K(gl)SNFSLEDFQHSK_
HSD17B7 Ubiquitylation K329 0.319 0.113 _VTIQK(gl)TDNQAR_

Background Information for HSD17B7:


Pubmed-HSD17B7 »
Uniprot-HSD17B7 »
Biogrid-HSD17B7 »
ProteomicsDB-HSD17B7 »

Tumorportal-HSD17B7 »
COSMIC-HSD17B7 »
GenomeRNAi-HSD17B7 »
Genecards-HSD17B7


Protein-protein Interactions for HSD17B7
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C1orf85 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSD17B7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC18A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC37A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSD17B7
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Epimerase_deHydtase_N IPR001509 0
Category members DH_sc/Rdtase_SDR IPR002198 0
Category members Glc/ribitol_DH IPR002347 0
Category members PKS_KR IPR013968 0


Protein complexes (CORUM database) featuring HSD17B7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HSD17B7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members Pathway Pathway_162 KEGG_STEROID_BIOSYNTHESIS 0 0
Category members Pathway Pathway_164 REACTOME_CHOLESTEROL_BIOSYNTHESIS 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_89 KEGG_STEROID_HORMONE_BIOSYNTHESIS 0 0
Category members GO Category GO:0000253 3-keto sterol reductase activity Database 0
Category members GO Category GO:0004303 estradiol 17-beta-dehydrogenase activity Database 0
Category members GO Category GO:0005148 prolactin receptor binding Database 0
Category members GO Category GO:0006695 cholesterol biosynthetic process Database 0
Category members GO Category GO:0006703 estrogen biosynthetic process Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0050662 coenzyme binding Database 0


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