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Query: HNRNPA2B1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HNRNPA2B1 0 1.047 -0.800 0.960 0.214 -0.888 -0.091

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HNRNPA2B1 Ubiquitylation K112 -0.597 0.042 _EESGKPGAHVTVK(gl)K_
HNRNPA2B1 Ubiquitylation K59 -0.662 -0.125 _LTDCVVM(ox)RDPASK(gl)R_
HNRNPA2B1 Phosphorylation S341 0.340 -0.309 _NMGGPYGGGNYGPGGS(ph)GGSGGYGGR_
HNRNPA2B1 Phosphorylation S259 -0.344 -0.331 _GFGDGYNGYGGGPGGGNFGGS(ph)PGYGGGR_
HNRNPA2B1 Ubiquitylation K113 -0.200 -0.352 _EESGKPGAHVTVKK(gl)_
HNRNPA2B1 Ubiquitylation K3 -0.702 -0.429 _(ac)MEK(gl)TLETVPLER_
HNRNPA2B1 Phosphorylation S344 -0.261 -0.504 _NM(ox)GGPYGGGNYGPGGSGGS(ph)GGYGGR_

Background Information for HNRNPA2B1:


Pubmed-HNRNPA2B1 »
Uniprot-HNRNPA2B1 »
Biogrid-HNRNPA2B1 »
ProteomicsDB-HNRNPA2B1 »

Tumorportal-HNRNPA2B1 »
COSMIC-HNRNPA2B1 »
GenomeRNAi-HNRNPA2B1 »
Genecards-HNRNPA2B1


Protein-protein Interactions for HNRNPA2B1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXW11 Cat. description Hein, Mann, Cell 2015
Category members IP bait FUS Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA3 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPD Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPH2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CC Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TAF15 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015


Protein Domains in HNRNPA2B1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members HnRNPA1 IPR021662 0


Protein complexes (CORUM database) featuring HNRNPA2B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 999 p23 protein complex Database 0


Categories featuring HNRNPA2B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0048025 negative regulation of mRNA splicing, via spliceosome Database 2.79
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Disease phenotype INCLUSION_BODY_MYOPATHY_WITH_EARLY-ONSET_PAGET_DISEASE_WITH_OR_WITHOUT INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT Database 0.11
Category members Disease phenotype Inclusion_body_myopathy_with_Paget_disease_of_bone_and_frontotemporal_dementia Inclusion body myopathy with Paget disease of bone and frontotemporal dementia Database 0.11
Category members GO Category GO:0043047 single-stranded telomeric DNA binding Database 0
Category members GO Category GO:0050658 RNA transport Database 0


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