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Query: HLTF

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HLTF 0 -0.758 0.090 0.760
HLTF 0 -0.758 0.090 0.760 -1.266 -1.379 -0.452 0.279 0.321

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HLTF Ubiquitylation K349 0.801 _LGGNNTSEK(gl)ADGLSK_
HLTF Ubiquitylation K952 0.264 _LGQK(gl)QEVIITK_
HLTF Ubiquitylation K889 0.024 _LDGSMAQKK(gl)_
HLTF Ubiquitylation K682 -1.157 0.020 _IYQSVK(gl)NEGR_
HLTF Ubiquitylation K999 0.178 -1.364 _QAK(gl)INEIR_
HLTF Ubiquitylation K95 -1.182 -1.582 _DPNNPYDK(gl)NAIK_
HLTF Ubiquitylation K988 -1.543 _ELAAGAFGTK(gl)KPNADEMK_

Background Information for HLTF:


Pubmed-HLTF »
Uniprot-HLTF »
Biogrid-HLTF »
ProteomicsDB-HLTF »

Tumorportal-HLTF »
COSMIC-HLTF »
GenomeRNAi-HLTF »
Genecards-HLTF


Protein-protein Interactions for HLTF
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP4S1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CERK Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GET4 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC1A Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TCEAL4 Cat. description Hein, Mann, Cell 2015
Category members IP bait APLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHD1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PMPCA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HLTF
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Znf_RING IPR001841 0


Protein complexes (CORUM database) featuring HLTF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HLTF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0016874 ligase activity Database 0


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