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Query: HIST1H2BC

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HIST1H2BC 1 2.985 -0.640 0.760
HIST1H2BC 1 2.985 -0.640 0.760 -0.763 -0.031 0.617

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HIST1H2BC Ubiquitylation K44 1.903 _ESYSVYVYK(gl)VLK_
HIST1H2BC Ubiquitylation K47 0.349 1.603 _VLK(gl)QVHPDTGISSK_
HIST1H2BC Ubiquitylation K117 0.346 1.538 _HAVSEGTK(gl)AVTK_
HIST1H2BC Ubiquitylation K109 0.117 0.362 _LLLPGELAK(gl)HAVSEGTK_
HIST1H2BC Ubiquitylation K121 -0.997 0.088 _AVTK(gl)YTSSK_
HIST1H2BC Ubiquitylation K6 -1.265 -0.686 _PEPAK(gl)SAPAPK_
HIST1H2BC Ubiquitylation K35 -0.211 _SRK(gl)ESYSVYVYK_
HIST1H2BC Ubiquitylation K86 0.468 _LAHYNK(gl)R_

Background Information for HIST1H2BC:


Pubmed-HIST1H2BC »
Uniprot-HIST1H2BC »
Biogrid-HIST1H2BC »
ProteomicsDB-HIST1H2BC »

Tumorportal-HIST1H2BC »
COSMIC-HIST1H2BC »
GenomeRNAi-HIST1H2BC »
Genecards-HIST1H2BC


Protein-protein Interactions for HIST1H2BC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMPO Cat. description Hein, Mann, Cell 2015


Protein Domains in HIST1H2BC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Histone_core_D IPR007125 0.12
Category members Histone-fold IPR009072 0.01
Category members Histone_H2B IPR000558 0
Category members CBFA_NFYB_domain IPR003958 0


Protein complexes (CORUM database) featuring HIST1H2BC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HIST1H2BC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_351 REACTOME_RNA_POL_I_TRANSCRIPTION 0 8.31
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members Pathway Pathway_1281 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE 0 4.19
Category members Pathway Pathway_1312 REACTOME_PACKAGING_OF_TELOMERE_ENDS 0 4.09
Category members GO Category GO:0006334 nucleosome assembly Database 3.77
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members Pathway Pathway_1139 REACTOME_RNA_POL_I_PROMOTER_OPENING 0 3.56
Category members GO Category GO:0000786 nucleosome Database 2.41
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_889 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 0.9
Category members Pathway Pathway_920 REACTOME_AMYLOIDS 0 0.68
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0042742 defense response to bacterium Database 0.06


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