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Query: HIST1H1E

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HIST1H1E 2 -1.220 0.010 0.000
HIST1H1E 2 -1.220 0.010 0.000 -2.077 -1.246 -0.337 -1.149 -1.118

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HIST1H1E Ubiquitylation K97 0.052 3.473 _GTLVQTK(gl)GTGASGSFK_
HIST1H1E Ubiquitylation K75 1.615 2.152 _KALAAAGYDVEK(gl)NNSR_
HIST1H1E Ubiquitylation K85 1.137 1.765 _LGLK(gl)SLVSK_
HIST1H1E Ubiquitylation K34 1.125 1.574 _K(gl)ASGPPVSELITK_
HIST1H1E Ubiquitylation K64 1.076 1.046 _K(gl)ALAAAGYDVEKNNSR_
HIST1H1E Ubiquitylation K90 -0.158 0.945 _SLVSK(gl)GTLVQTK_
HIST1H1E Ubiquitylation K106 0.973 0.893 _GTGASGSFK(gl)LNKK_
HIST1H1E Ubiquitylation K46 0.238 0.432 _KASGPPVSELITK(gl)AVAASK_
HIST1H1E Phosphorylation S36 -0.319 _RKAS(ph)GPPVSELITK_
HIST1H1E Phosphorylation T4 -1.741 -0.745 _(ac)SET(ph)APAAPAAPAPAEK_
HIST1H1E Ubiquitylation K17 -1.478 -1.212 _(ac)SETAPAAPAAPAPAEK(gl)TPVKK_
HIST1H1E Ubiquitylation K21 -1.478 -1.212 _(ac)SETAPAAPAAPAPAEK(gl)TPVK(gl)K_
HIST1H1E Ubiquitylation K22 -1.250 -1.212 _(ac)SETAPAAPAAPAPAEK(gl)TPVK(gl)K_
HIST1H1E Phosphorylation S2 -1.308 -1.220 _S(ph)ETAPAAPAAPAPAEK_
HIST1H1E Phosphorylation T18 -2.773 -1.986 _(ac)S(ph)ETAPAAPAAPAPAEKT(ph)PVKK_
HIST1H1E Ubiquitylation K63 -0.481 _SGVSLAALK(gl)K_

Background Information for HIST1H1E:





Protein-protein Interactions for HIST1H1E

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C10orf12 Cat. description Hein, Mann, Cell 2015
Category members IP bait DHX57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EBNA1BP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GAR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1T Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LARP1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL10A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZCRB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HIST1H1E

Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Histone_H1/H5_H15 IPR005818 0.14
Category members Histone_H5 IPR005819 0.08


Protein complexes (CORUM database) featuring HIST1H1E

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HIST1H1E

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006334 nucleosome assembly Database 3.77
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members GO Category GO:0000786 nucleosome Database 2.41
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_955 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION 0 0.51
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members GO Category GO:0016584 nucleosome positioning Database 0


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