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Query: HERC4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HERC4 2 1.441 2.840 -1.140 -0.379

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HERC4 Ubiquitylation K177 1.820 _YGQLGLGTDCKK(gl)_
HERC4 Ubiquitylation K176 -0.279 _YGQLGLGTDCK(gl)K_

Background Information for HERC4:


Pubmed-HERC4 »
Uniprot-HERC4 »
Biogrid-HERC4 »
ProteomicsDB-HERC4 »

Tumorportal-HERC4 »
COSMIC-HERC4 »
GenomeRNAi-HERC4 »
Genecards-HERC4


Protein-protein Interactions for HERC4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait ESRRB Cat. description Hein, Mann, Cell 2015
Category members IP bait GMNN Cat. description Hein, Mann, Cell 2015
Category members IP bait KATNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIN7C Cat. description Hein, Mann, Cell 2015
Category members IP bait NUF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP6C Cat. description Hein, Mann, Cell 2015
Category members IP bait RB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALOXE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APOBEC3D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C1orf94 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FDXACB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MOCS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NLRX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WRAP73 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HERC4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RCC1/BLIP-II IPR009091 0.24
Category members Reg_chr_condens IPR000408 0.23
Category members HECT IPR000569 0.04


Protein complexes (CORUM database) featuring HERC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HERC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0007283 spermatogenesis Database 0


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