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Query: GUCY1B3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GUCY1B3 0 1.341 -0.550 -0.060

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GUCY1B3 Ubiquitylation K583 1.401 _GK(gl)INVSEYTYR_
GUCY1B3 Ubiquitylation K237 -0.565 _ISPYTFCK(gl)_

Background Information for GUCY1B3:


Pubmed-GUCY1B3 »
Uniprot-GUCY1B3 »
Biogrid-GUCY1B3 »
ProteomicsDB-GUCY1B3 »

Tumorportal-GUCY1B3 »
COSMIC-GUCY1B3 »
GenomeRNAi-GUCY1B3 »
Genecards-GUCY1B3


Protein-protein Interactions for GUCY1B3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANKMY2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GUCY1B3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NOX5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GUCY1B3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members A/G_cyclase IPR001054 0
Category members Heme_NO-bd IPR011644 0
Category members Haem_no_assoc-bd IPR011645 0
Category members NO_sig/Golgi_transp_ligand-bd IPR024096 0
Category members Nucleotide_cyclase IPR029787 0


Protein complexes (CORUM database) featuring GUCY1B3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 407 Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3) Database 0
Category members Corum 408 Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3) Database 0


Categories featuring GUCY1B3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members Pathway Pathway_285 REACTOME_PLATELET_HOMEOSTASIS 0 0.08
Category members GO Category GO:0020037 heme binding Database 0.04
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members Pathway Pathway_287 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE 0 0
Category members GO Category GO:0004383 guanylate cyclase activity Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0006182 cGMP biosynthetic process Database 0
Category members GO Category GO:0007263 nitric oxide mediated signal transduction Database 0
Category members GO Category GO:0008015 blood circulation Database 0
Category members GO Category GO:0008074 guanylate cyclase complex, soluble Database 0
Category members GO Category GO:0009190 cyclic nucleotide biosynthetic process Database 0
Category members GO Category GO:0016849 phosphorus-oxygen lyase activity Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051879 Hsp90 protein binding Database 0


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