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Query: GNA13

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GNA13 1 2.993 0.350 -0.930 0.375 0.243

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GNA13 Ubiquitylation K66 1.633 _STFLK(gl)QMR_
GNA13 Ubiquitylation K36 0.742 1.351 _EIDK(gl)CLSR_

Background Information for GNA13:


Pubmed-GNA13 »
Uniprot-GNA13 »
Biogrid-GNA13 »
ProteomicsDB-GNA13 »

Tumorportal-GNA13 »
COSMIC-GNA13 »
GenomeRNAi-GNA13 »
Genecards-GNA13


Protein-protein Interactions for GNA13
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CYP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DUSP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FANCE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait S1PR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM185A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM206 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GNA13
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Gprotein_alpha_12 IPR000469 0.22
Category members GproteinA_insert IPR011025 0.18
Category members Gprotein_alpha_su IPR001019 0.02


Protein complexes (CORUM database) featuring GNA13
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GNA13
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_736 PID_S1P_META_PATHWAY 0 0.73
Category members Pathway Pathway_1078 PID_S1P_S1P2_PATHWAY 0 0.62
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members Pathway Pathway_677 BIOCARTA_MYOSIN_PATHWAY 0 0.53
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members Pathway Pathway_987 PID_S1P_S1P3_PATHWAY 0 0.28
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Pathway Pathway_428 PID_THROMBIN_PAR1_PATHWAY 0 0.18
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members Pathway Pathway_696 PID_S1P_S1P4_PATHWAY 0 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway Database 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0031234 extrinsic to cytoplasmic side of plasma membrane Database 0.1
Category members GO Category GO:0001664 G-protein coupled receptor binding Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0019001 guanyl nucleotide binding Database 0.07
Category members Pathway Pathway_721 REACTOME_SIGNAL_AMPLIFICATION 0 0.06
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0031752 D5 dopamine receptor binding Database 0.03
Category members GO Category GO:0031683 G-protein beta/gamma-subunit complex binding Database 0.02
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members Pathway Pathway_1099 BIOCARTA_AKAP13_PATHWAY 0 0
Category members Pathway Pathway_1103 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members Pathway Pathway_658 ST_GA13_PATHWAY 0 0
Category members Pathway Pathway_684 PID_THROMBIN_PAR4_PATHWAY 0 0
Category members Pathway Pathway_994 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001569 patterning of blood vessels Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005834 heterotrimeric G-protein complex Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007204 positive regulation of cytosolic calcium ion concentration Database 0
Category members GO Category GO:0007266 Rho protein signal transduction Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0031526 brush border membrane Database 0
Category members GO Category GO:0031584 activation of phospholipase D activity Database 0
Category members GO Category GO:0031702 type 1 angiotensin receptor binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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