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Query: GARS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GARS 0 -0.073 0.600 0.070 -0.091 -0.963 -1.068 0.415 0.276

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GARS Ubiquitylation K99 0.546 0.812 _AVAELK(gl)AR_
GARS Ubiquitylation K129 0.405 _MEDTLK(gl)R_
GARS Ubiquitylation K559 -0.409 -0.291 _DMINVK(gl)R_
GARS Ubiquitylation K82 -0.419 _LK(gl)EDKAPQVDVDK_
GARS Ubiquitylation K108 0.135 _VLEAK(gl)ELALQPK_
GARS Ubiquitylation K207 0.107 _DVK(gl)NGECFR_
GARS Ubiquitylation K224 0.110 _AHLQK(gl)LMSDKK_
GARS Ubiquitylation K506 0.535 _GAIGK(gl)AYKK_
GARS Ubiquitylation K733 0.251 _YPLFEGQETGK(gl)KETIEE_
GARS Ubiquitylation K734 0.251 _YPLFEGQETGK(gl)KETIEE_

Background Information for GARS:


Pubmed-GARS »
Uniprot-GARS »
Biogrid-GARS »
ProteomicsDB-GARS »

Tumorportal-GARS »
COSMIC-GARS »
GenomeRNAi-GARS »
Genecards-GARS


Protein-protein Interactions for GARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PSMC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members S15_NS1_RNA-bd IPR009068 0.28
Category members WHEP-TRS IPR000738 0.27
Category members aa-tRNA-synth_II IPR006195 0.24
Category members aa-tRNA-synt_IIb_cons-dom IPR002314 0
Category members Anticodon-bd IPR004154 0


Protein complexes (CORUM database) featuring GARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members GO Category GO:0030141 secretory granule Database 0.11
Category members GO Category GO:0008219 cell death Database 0.08
Category members Pathway Pathway_203 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION 0 0
Category members Disease phenotype Distal_hereditary_motor_neuropathy_type_5 Distal hereditary motor neuropathy type 5 Database 0
Category members Disease phenotype NEURONOPATHY_DISTAL_HEREDITARY_MOTOR_TYPE_VA NEURONOPATHY DISTAL HEREDITARY MOTOR TYPE VA Database 0
Category members GO Category GO:0015966 diadenosine tetraphosphate biosynthetic process Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0


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