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Query: FECH

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FECH 0 -0.670 -0.500 0.450 -0.388 -0.516 -0.216

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for FECH:


Pubmed-FECH »
Uniprot-FECH »
Biogrid-FECH »
ProteomicsDB-FECH »

Tumorportal-FECH »
COSMIC-FECH »
GenomeRNAi-FECH »
Genecards-FECH


Protein-protein Interactions for FECH
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CYP1A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FECH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNA15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MMP26 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NIT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2CB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCBTB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TIMP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMOD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMOD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FECH
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring FECH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FECH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0010999 regulation of eIF2 alpha phosphorylation by heme Database 0.18
Category members GO Category GO:0046501 protoporphyrinogen IX metabolic process Database 0.18
Category members GO Category GO:0046984 regulation of hemoglobin biosynthetic process Database 0.18
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0030218 erythrocyte differentiation Database 0.13
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0009416 response to light stimulus Database 0.06
Category members GO Category GO:0005506 iron ion binding Database 0.04
Category members GO Category GO:0020037 heme binding Database 0.04
Category members Pathway Pathway_81 KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM 0 0.01
Category members Pathway Pathway_403 BIOCARTA_AHSP_PATHWAY 0 0
Category members Pathway Pathway_88 REACTOME_METABOLISM_OF_PORPHYRINS 0 0
Category members Disease phenotype Erythropoietic_protoporphyria Erythropoietic protoporphyria Database 0
Category members GO Category GO:0006091 generation of precursor metabolites and energy Database 0
Category members GO Category GO:0006778 porphyrin-containing compound metabolic process Database 0
Category members GO Category GO:0006779 porphyrin-containing compound biosynthetic process Database 0
Category members GO Category GO:0006783 heme biosynthetic process Database 0
Category members GO Category GO:0008198 ferrous iron binding Database 0
Category members GO Category GO:0010038 response to metal ion Database 0
Category members GO Category GO:0010288 response to lead ion Database 0
Category members GO Category GO:0017085 response to insecticide Database 0
Category members GO Category GO:0030350 iron-responsive element binding Database 0
Category members GO Category GO:0034379 very-low-density lipoprotein particle assembly Database 0
Category members GO Category GO:0046685 response to arsenic-containing substance Database 0
Category members GO Category GO:0051537 2 iron, 2 sulfur cluster binding Database 0
Category members GO Category GO:0051597 response to methylmercury Database 0
Category members GO Category GO:0055072 iron ion homeostasis Database 0
Category members GO Category GO:0070541 response to platinum ion Database 0


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