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Query: FBXO11

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FBXO11 1 -0.447 2.850 -1.250 -0.514 0.964

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FBXO11 Ubiquitylation K871 -0.905 0.008 _NAICVNCIKK(gl)_

Background Information for FBXO11:


Pubmed-FBXO11 »
Uniprot-FBXO11 »
Biogrid-FBXO11 »
ProteomicsDB-FBXO11 »

Tumorportal-FBXO11 »
COSMIC-FBXO11 »
GenomeRNAi-FBXO11 »
Genecards-FBXO11


Protein-protein Interactions for FBXO11
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP3S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKAIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C11orf48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC107 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFA6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOSL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXJ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPB6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKZF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIRREL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRDM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCML4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOCS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAU1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCP10L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THAP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF10A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WWP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF263 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF692 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF71 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNRF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FBXO11
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members F-box_dom IPR001810 0
Category members Znf_N-recognin IPR003126 0
Category members PbH1 IPR006626 0
Category members Carb-bd_sugar_hydrolysis-dom IPR006633 0
Category members Pectin_lyase_fold/virulence IPR011050 0
Category members Znf_N-recognin_met IPR013993 0
Category members Para_beta_helix_rpt-2 IPR022441 0


Protein complexes (CORUM database) featuring FBXO11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1260 Neddylin ligase (FBXO11, SKP1, CUL1, RBX1) Database 0


Categories featuring FBXO11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005694 chromosome Database 3.87
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0000151 ubiquitin ligase complex Database 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0016274 protein-arginine N-methyltransferase activity Database 0
Category members GO Category GO:0035246 peptidyl-arginine N-methylation Database 0


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