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Query: FBL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FBL 0 3.049 -0.770 0.790 -0.287 0.982 0.086

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FBL Phosphorylation S124 0.477 0.584 _RVS(ph)ISEGDDKIEYR_
FBL Ubiquitylation K205 0.098 -0.320 _DLINLAK(gl)K(gl)R_
FBL Ubiquitylation K102 0.737 -0.350 _GK(gl)EDALVTK_
FBL Ubiquitylation K285 0.533 -0.772 _ANCIDSTASAEAVFASEVKK(gl)_
FBL Ubiquitylation K131 -0.792 _VSISEGDDK(gl)IEYR_
FBL Ubiquitylation K206 0.127 -0.846 _DLINLAK(gl)K(gl)R_
FBL Ubiquitylation K284 -1.007 _ANCIDSTASAEAVFASEVK(gl)K_
FBL Ubiquitylation K109 -0.532 -1.093 _GKEDALVTK(gl)NLVPGESVYGEKR_
FBL Ubiquitylation K121 -0.496 -1.255 _NLVPGESVYGEK(gl)R_
FBL Ubiquitylation K292 -1.714 _MQQENM(ox)K(gl)PQEQLTLEPYER_

Background Information for FBL:


Pubmed-FBL »
Uniprot-FBL »
Biogrid-FBL »
ProteomicsDB-FBL »

Tumorportal-FBL »
COSMIC-FBL »
GenomeRNAi-FBL »
Genecards-FBL


Protein-protein Interactions for FBL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBL Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP56 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHST8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEUROG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FBL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAM-dependent_MTases-like IPR029063 0.04
Category members Fibrillarin IPR000692 0
Category members tRNA_MeTrfase_Gcd14 IPR014816 0


Protein complexes (CORUM database) featuring FBL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 5266 TNF-alpha/NF-kappa B signaling complex 6 Database 3.74
Category members Corum 929 CEN complex Database 3.25
Category members Corum 1231 FIB-associated protein complex Database 0


Categories featuring FBL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0006364 rRNA processing Database 2.47
Category members GO Category GO:0031428 box C/D snoRNP complex Database 0.79
Category members Pathway Pathway_402 BIOCARTA_SARS_PATHWAY 0 0.64
Category members GO Category GO:0008033 tRNA processing Database 0.39
Category members GO Category GO:0015030 Cajal body Database 0.04
Category members GO Category GO:0001652 granular component Database 0
Category members GO Category GO:0008168 methyltransferase activity Database 0
Category members GO Category GO:0016429 tRNA (adenine-N1-)-methyltransferase activity Database 0
Category members GO Category GO:0030488 tRNA methylation Database 0
Category members GO Category GO:0031515 tRNA (m1A) methyltransferase complex Database 0


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