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Query: EXT2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EXT2 0 1.843 -1.290 1.340

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EXT2 Ubiquitylation K181 0.503 _IK(gl)ETAQAMAQLSR_
EXT2 Ubiquitylation K126 0.339 _VYIYALKK(gl)_
EXT2 Ubiquitylation K531 0.165 _TAENK(gl)LSNR_
EXT2 Ubiquitylation K523 -0.044 _VPLK(gl)VVR_

Background Information for EXT2:


Pubmed-EXT2 »
Uniprot-EXT2 »
Biogrid-EXT2 »
ProteomicsDB-EXT2 »

Tumorportal-EXT2 »
COSMIC-EXT2 »
GenomeRNAi-EXT2 »
Genecards-EXT2


Protein-protein Interactions for EXT2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EXT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EXT2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Nucleotide-diphossugar_trans IPR029044 0.21
Category members Exostosin IPR004263 0.03
Category members HexNAc_Trfase_a IPR015338 0


Protein complexes (CORUM database) featuring EXT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EXT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_73 REACTOME_GLYCOSAMINOGLYCAN_METABOLISM 0 1.71
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0030203 glycosaminoglycan metabolic process Database 1.44
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_79 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM 0 0.49
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_478 REACTOME_HS_GAG_BIOSYNTHESIS 0 0.31
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0006486 protein glycosylation Database 0.21
Category members GO Category GO:0016757 transferase activity, transferring glycosyl groups Database 0.19
Category members GO Category GO:0006024 glycosaminoglycan biosynthetic process Database 0.18
Category members GO Category GO:0001707 mesoderm formation Database 0.11
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members Pathway Pathway_477 KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE 0 0.04
Category members Disease phenotype Multiple_osteochondromas Multiple osteochondromas Database 0
Category members Disease phenotype Potocki-Shaffer_syndrome Potocki-Shaffer syndrome Database 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008375 acetylglucosaminyltransferase activity Database 0
Category members GO Category GO:0015012 heparan sulfate proteoglycan biosynthetic process Database 0
Category members GO Category GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process Database 0
Category members GO Category GO:0015020 glucuronosyltransferase activity Database 0
Category members GO Category GO:0016758 transferase activity, transferring hexosyl groups Database 0
Category members GO Category GO:0031227 intrinsic to endoplasmic reticulum membrane Database 0
Category members GO Category GO:0033692 cellular polysaccharide biosynthetic process Database 0
Category members GO Category GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Database 0
Category members GO Category GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Database 0


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