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Query: EIF5A2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF5A2 0 2.630 -0.580 0.130 -0.044 1.340 -1.175 0.031 0.025

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF5A2 Ubiquitylation K39 1.330 0.690 _GRPCK(gl)IVEM(ox)STSK_
EIF5A2 Phosphorylation T9 -0.003 0.305 _ADDLDFET(ph)GDAGASATFPM(ox)QCSALR_
EIF5A2 Ubiquitylation K27 -0.023 -0.373 _K(gl)NGFVVLK_
EIF5A2 Ubiquitylation K34 -0.015 -0.550 _NGFVVLK(gl)GRPCK_
EIF5A2 Ubiquitylation K85 -0.842 -0.793 _YEDICPSTHNMDVPNIK(gl)R_
EIF5A2 Ubiquitylation K67 0.127 _VHLVGIDIFTGK(gl)K_
EIF5A2 Ubiquitylation K68 0.088 _VHLVGIDIFTGKK(gl)_
EIF5A2 Ubiquitylation K121 -0.654 _EDLRLPEGDLGK(gl)EIEQK_

Background Information for EIF5A2:


Pubmed-EIF5A2 »
Uniprot-EIF5A2 »
Biogrid-EIF5A2 »
ProteomicsDB-EIF5A2 »

Tumorportal-EIF5A2 »
COSMIC-EIF5A2 »
GenomeRNAi-EIF5A2 »
Genecards-EIF5A2


Protein-protein Interactions for EIF5A2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DOHH Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF5A2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members Translation_prot_SH3-like IPR008991 0.29
Category members KOW IPR005824 0.16
Category members Transl_elong_IF5A IPR001884 0
Category members Transl_elong_IF5A_C IPR020189 0


Protein complexes (CORUM database) featuring EIF5A2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF5A2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005643 nuclear pore Database 6.58
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0051028 mRNA transport Database 1.7
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0043022 ribosome binding Database 0.33
Category members GO Category GO:0003746 translation elongation factor activity Database 0.08
Category members Pathway Pathway_179 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION 0 0.06
Category members Pathway Pathway_94 REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 0 0
Category members GO Category GO:0006452 translational frameshifting Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008612 peptidyl-lysine modification to hypusine Database 0
Category members GO Category GO:0043687 post-translational protein modification Database 0
Category members GO Category GO:0045901 positive regulation of translational elongation Database 0
Category members GO Category GO:0045905 positive regulation of translational termination Database 0


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