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Query: EIF3B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF3B 0 4.071 1.370 -0.495 -0.796 0.313 0.383

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF3B Ubiquitylation K213 0.753 0.706 _IFSK(gl)FGK_
EIF3B Phosphorylation S117 0.195 0.691 _S(ph)DSRAQAVSEDAGGNEGR_
EIF3B Ubiquitylation K254 0.780 0.552 _NADGYK(gl)LDKQHTFR_
EIF3B Ubiquitylation K364 -0.136 0.294 _GIALWGGEK(gl)FK_
EIF3B Phosphorylation S119 0.751 0.135 _SDS(ph)RAQAVSEDAGGNEGR_
EIF3B Ubiquitylation K228 -0.141 _ITNDFYPEEDGK(gl)TK_
EIF3B Ubiquitylation K230 -0.197 -0.141 _ITNDFYPEEDGKTK(gl)_
EIF3B Ubiquitylation K744 -0.170 _ASK(gl)ELVER_
EIF3B Ubiquitylation K324 -0.666 -0.221 _TSIFWNDVK(gl)DPVSIEER_
EIF3B Ubiquitylation K463 -0.222 _SLK(gl)ISGIK_
EIF3B Ubiquitylation K535 -0.160 -0.820 _TPK(gl)GTQGVVTNFEIFR_
EIF3B Phosphorylation S85 -3.958 _TEPAAEAEAASGPSESPS(ph)PPAAEELPGSHAEPPVPAQGEAPGEQAR_
EIF3B Ubiquitylation K209 1.149 _LKNVIHK(gl)_
EIF3B Ubiquitylation K257 0.112 _LDK(gl)QHTFR_
EIF3B Ubiquitylation K288 -0.482 _QPFK(gl)DLGNLR_
EIF3B Ubiquitylation K529 0.371 _NGDYLCVK(gl)VDR_
EIF3B Ubiquitylation K552 -0.586 _EK(gl)QVPVDVVEMK_
EIF3B Ubiquitylation K729 -0.119 _YSK(gl)IFEQK_
EIF3B Ubiquitylation K734 0.515 _IFEQK(gl)DR_
EIF3B Ubiquitylation K762 -0.137 _K(gl)MAQELYMEQK_
EIF3B Ubiquitylation K772 0.011 _MAQELYMEQK(gl)NER_

Background Information for EIF3B:


Pubmed-EIF3B »
Uniprot-EIF3B »
Biogrid-EIF3B »
ProteomicsDB-EIF3B »

Tumorportal-EIF3B »
COSMIC-EIF3B »
GenomeRNAi-EIF3B »
Genecards-EIF3B


Protein-protein Interactions for EIF3B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait ITSN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3F Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3H Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3I Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3M Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RSPH9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF3B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members WD40_repeat_dom IPR017986 1.39
Category members TIF_beta_prop-like IPR013979 1.21


Protein complexes (CORUM database) featuring EIF3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 742 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) Database 1.74
Category members Corum 1097 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) Database 1.41
Category members Corum 4392 EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) Database 0.43
Category members Corum 4389 EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I) Database 0.18
Category members Corum 4399 EIF3 complex (EIF3B, EIF3J, EIF3I) Database 0.07
Category members Corum 4403 EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) Database 0.05
Category members Corum 4395 EIF3 complex (EIF3B, EIF3G, EIF3I) Database 0


Categories featuring EIF3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_769 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005852 eukaryotic translation initiation factor 3 complex Database 2.27
Category members GO Category GO:0033290 eukaryotic 48S preinitiation complex Database 1.41
Category members GO Category GO:0001731 formation of translation preinitiation complex Database 1.15
Category members GO Category GO:0016282 eukaryotic 43S preinitiation complex Database 1.15
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0032947 protein complex scaffold Database 0.82
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0031369 translation initiation factor binding Database 0.1
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04


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