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Query: EIF3A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF3A 4 10.341 -2.100 4.390 1.636 -0.539 -0.870 -0.336 -0.006

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF3A Ubiquitylation K777 1.253 3.661 _LK(gl)QFEER_
EIF3A Ubiquitylation K603 1.501 1.065 _EAELQK(gl)VR_
EIF3A Ubiquitylation K351 0.570 0.759 _LLDMDGIIVEK(gl)QR_
EIF3A Ubiquitylation K409 0.925 0.382 _VTK(gl)VLNWVR_
EIF3A Phosphorylation S881 0.249 0.319 _RLGDS(ph)SLSR_
EIF3A Phosphorylation S882 -0.148 0.319 _LGDSS(ph)LSR_
EIF3A Ubiquitylation K775 -0.180 -0.313 _QSVYEEK(gl)LKQFEER_
EIF3A Phosphorylation S1336 -0.904 -0.762 _RVPPPALS(ph)R_
EIF3A Ubiquitylation K591 1.447 _EK(gl)EELEQR_
EIF3A Ubiquitylation K632 1.585 _ILQEHEQIK(gl)K_
EIF3A Ubiquitylation K651 0.237 _TELGAK(gl)AFK_
EIF3A Ubiquitylation K679 1.837 _QVEQLEK(gl)EKK_
EIF3A Ubiquitylation K694 1.339 _K(gl)IDYFER_
EIF3A Ubiquitylation K711 1.654 _LEEIPLIK(gl)SAYEEQR_
EIF3A Ubiquitylation K824 -0.025 _AEEQMLK(gl)ER_

Background Information for EIF3A:


Pubmed-EIF3A »
Uniprot-EIF3A »
Biogrid-EIF3A »
ProteomicsDB-EIF3A »

Tumorportal-EIF3A »
COSMIC-EIF3A »
GenomeRNAi-EIF3A »
Genecards-EIF3A


Protein-protein Interactions for EIF3A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait ITSN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF11 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CPNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3F Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3H Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3I Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3M Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPBP1L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RSPH9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF3A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PCI_dom IPR000717 2.22


Protein complexes (CORUM database) featuring EIF3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 742 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) Database 1.74
Category members Corum 1097 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) Database 1.41
Category members Corum 4392 EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) Database 0.43
Category members Corum 4389 EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I) Database 0.18
Category members Corum 4403 EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) Database 0.05


Categories featuring EIF3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_769 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005852 eukaryotic translation initiation factor 3 complex Database 2.27
Category members GO Category GO:0033290 eukaryotic 48S preinitiation complex Database 1.41
Category members GO Category GO:0001731 formation of translation preinitiation complex Database 1.15
Category members GO Category GO:0016282 eukaryotic 43S preinitiation complex Database 1.15
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0001732 formation of translation initiation complex Database 0.11
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0


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