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Query: EIF2AK4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF2AK4 0 -0.606 -0.850 1.010

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF2AK4 Ubiquitylation K1135 0.142 _NNILNLK(gl)R_
EIF2AK4 Phosphorylation T667 -1.139 -1.215 _HERPAGPGT(ph)PPPDSGPLAK_
EIF2AK4 Ubiquitylation K619 0.596 _LDGCCYAVK(gl)R_

Background Information for EIF2AK4:


Pubmed-EIF2AK4 »
Uniprot-EIF2AK4 »
Biogrid-EIF2AK4 »
ProteomicsDB-EIF2AK4 »

Tumorportal-EIF2AK4 »
COSMIC-EIF2AK4 »
GenomeRNAi-EIF2AK4 »
Genecards-EIF2AK4


Protein-protein Interactions for EIF2AK4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EDC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRPPRC Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEPT11 Cat. description Hein, Mann, Cell 2015
Category members IP bait C6orf141 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CROT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRYL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MDM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PALM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TKT Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF2AK4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Anticodon-bd IPR004154 0
Category members RWD-domain IPR006575 0
Category members UBQ-conjugating_enzyme/RWD IPR016135 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring EIF2AK4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF2AK4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_1174 BIOCARTA_EIF2_PATHWAY 0 0.22
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity Database 0.17
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04
Category members GO Category GO:0009267 cellular response to starvation Database 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Disease phenotype PULMONARY_VENOOCCLUSIVE_DISEASE PULMONARY VENOOCCLUSIVE DISEASE Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0022626 cytosolic ribosome Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043558 regulation of translational initiation in response to stress Database 0


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