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Query: EEF2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EEF2 2 8.912 1.690 -1.040 0.275 1.260 -0.448 0.479 0.184

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EEF2 Ubiquitylation K252 2.628 3.073 _K(gl)VEDMMK_
EEF2 Ubiquitylation K239 2.313 1.670 _FAAK(gl)GEGQLGPAER_
EEF2 Ubiquitylation K407 0.530 1.611 _MVPTSDK(gl)GR_
EEF2 Ubiquitylation K275 2.553 1.565 _FSK(gl)SATSPEGK_
EEF2 Ubiquitylation K235 1.302 _QFAEMYVAK(gl)FAAK_
EEF2 Ubiquitylation K272 2.208 1.292 _YFDPANGK(gl)FSK_
EEF2 Ubiquitylation K42 0.239 1.160 _STLTDSLVCK(gl)AGIIASAR_
EEF2 Ubiquitylation K525 1.009 _LVEGLK(gl)R_
EEF2 Phosphorylation T57 0.324 0.971 _FT(ph)DTRKDEQER_
EEF2 Ubiquitylation K314 0.865 0.938 _EETAK(gl)LIEK_
EEF2 Ubiquitylation K61 0.879 _FTDTRK(gl)DEQER_
EEF2 Ubiquitylation K594 0.581 0.785 _ETVSEESNVLCLSK(gl)SPNK_
EEF2 Ubiquitylation K152 0.436 0.689 _IK(gl)PVLM(ox)M(ox)NK(gl)M(ox)DR_
EEF2 Ubiquitylation K426 0.492 0.658 _VFSGLVSTGLK(gl)VR_
EEF2 Ubiquitylation K498 0.992 0.312 _VMK(gl)FSVSPVVR_
EEF2 Ubiquitylation K159 0.607 0.150 _IK(gl)PVLM(ox)M(ox)NK(gl)M(ox)DR_
EEF2 Phosphorylation T435 0.294 0.141 _IMGPNYT(ph)PGKK_
EEF2 Ubiquitylation K445 0.079 _EDLYLK(gl)PIQR_
EEF2 Ubiquitylation K572 -0.752 -0.207 _K(gl)SDPVVSYR_
EEF2 Ubiquitylation K283 -0.183 -0.664 _SATSPEGK(gl)KLPR_
EEF2 Ubiquitylation K512 -1.476 -1.170 _VAVEAK(gl)NPADLPK_
EEF2 Phosphorylation T59 0.490 _AGETRFTDT(ph)R_
EEF2 Ubiquitylation K251 1.049 _AK(gl)KVEDMMK_

Background Information for EEF2:


Pubmed-EEF2 »
Uniprot-EEF2 »
Biogrid-EEF2 »
ProteomicsDB-EEF2 »

Tumorportal-EEF2 »
COSMIC-EEF2 »
GenomeRNAi-EEF2 »
Genecards-EEF2


Protein-protein Interactions for EEF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM86A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EEF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members EF_GTP-bd_dom IPR000795 1.57
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06
Category members Small_GTP-bd_dom IPR005225 0.32
Category members Transl_B-barrel IPR009000 0.24
Category members Transl_elong_EFG/EF2_IV IPR005517 0.11
Category members EFG_V IPR000640 0
Category members Transl_elong_EFTu/EF1A_2 IPR004161 0
Category members EFG_III-V IPR009022 0


Protein complexes (CORUM database) featuring EEF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF


Categories featuring EEF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_768 REACTOME_PEPTIDE_CHAIN_ELONGATION 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006414 translational elongation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0005844 polysome Database 0.09
Category members GO Category GO:0003746 translation elongation factor activity Database 0.08


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