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Query: DYNC1I2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DYNC1I2 0 1.762 0.730 -0.890
DYNC1I2 0 1.762 0.730 -0.890 -0.096 0.035 -0.269

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DYNC1I2 Phosphorylation S94 -0.493 0.922 _SVS(ph)TPSEAGSQDSGDGAVGSR_
DYNC1I2 Phosphorylation T95 1.047 0.730 _SVST(ph)PSEAGSQDSGDGAVGSR_
DYNC1I2 Phosphorylation S101 0.309 _SVSTPSEAGS(ph)QDSGDGAVGSR_
DYNC1I2 Phosphorylation S73 1.170 0.160 _EAEALLQSMGLTPES(ph)PIVPPPMS(ph)PSSK_
DYNC1I2 Phosphorylation S81 -1.285 -1.122 _EAEALLQSMGLTPES(ph)PIVPPPMS(ph)PSSK_
DYNC1I2 Phosphorylation S84 -1.709 _EAEALLQSMGLTPESPIVPPPMSPSS(ph)K_

Background Information for DYNC1I2:


Pubmed-DYNC1I2 »
Uniprot-DYNC1I2 »
Biogrid-DYNC1I2 »
ProteomicsDB-DYNC1I2 »

Tumorportal-DYNC1I2 »
COSMIC-DYNC1I2 »
GenomeRNAi-DYNC1I2 »
Genecards-DYNC1I2


Protein-protein Interactions for DYNC1I2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C1orf63 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNC1H1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNC1LI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLRB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KDM1B Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAFAH1B1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAR2B Cat. description Hein, Mann, Cell 2015
Category members IP bait TSC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNC1I1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DYNC1LI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ITK Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DYNC1I2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members Dynein_IC_1/2 IPR025956 0


Protein complexes (CORUM database) featuring DYNC1I2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DYNC1I2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0007018 microtubule-based movement Database 0.75
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0003777 microtubule motor activity Database 0.49
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members GO Category GO:0031982 vesicle Database 0.01
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members GO Category GO:0005868 cytoplasmic dynein complex Database 0
Category members GO Category GO:0006810 transport Database 0


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