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Query: DSC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DSC2 0 -0.807 0.080 -0.120

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DSC2 Ubiquitylation K913 -0.807 _TLAEACMK(gl)R_

Background Information for DSC2:


Pubmed-DSC2 »
Uniprot-DSC2 »
Biogrid-DSC2 »
ProteomicsDB-DSC2 »

Tumorportal-DSC2 »
COSMIC-DSC2 »
GenomeRNAi-DSC2 »
Genecards-DSC2


Protein-protein Interactions for DSC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait JUP Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GMCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PI4KA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DSC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cadherin/Desmocollin IPR009124 1.19
Category members Cadherin_pro_dom IPR014868 0.78
Category members Cadherin IPR002126 0.32
Category members Cadherin_cytoplasmic-dom IPR000233 0.29
Category members Desmosomal_cadherin IPR009122 0.28
Category members Cadherin-like IPR015919 0.21


Protein complexes (CORUM database) featuring DSC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DSC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0007156 homophilic cell adhesion Database 0.28
Category members GO Category GO:0030057 desmosome Database 0.26
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_biventricular_form Familial isolated arrhythmogenic ventricular dysplasia biventricular form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_left_dominant_form Familial isolated arrhythmogenic ventricular dysplasia left dominant form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_right_dominant_form Familial isolated arrhythmogenic ventricular dysplasia right dominant form Database 0.05
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0007155 cell adhesion Database 0


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