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Query: DISC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DISC1 0 0.281 0.550 -0.420

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DISC1 Ubiquitylation K590 0.281 _SLNLSLK(gl)_

Background Information for DISC1:





Protein-protein Interactions for DISC1

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ASB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C17orf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRYBA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DYNC1I1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDEL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIBC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCL1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DISC1

Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring DISC1

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 6041 DISC-FEZ1 complex Database 0
Category members Corum 6043 DISC-FEZ1-F-actin complex Database 0
Category members Corum 6045 Database 0
Category members Corum 6046 Database 0


Categories featuring DISC1

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members Disease phenotype SCHIZOPHRENIA SCHIZOPHRENIA Database 0
Category members Disease phenotype SCHIZOPHRENIA_9 SCHIZOPHRENIA 9 Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0002052 positive regulation of neuroblast proliferation Database 0
Category members GO Category GO:0010975 regulation of neuron projection development Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0021799 cerebral cortex radially oriented cell migration Database 0
Category members GO Category GO:0021846 cell proliferation in forebrain Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0030177 positive regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0031929 TOR signaling Database 0
Category members GO Category GO:0051560 mitochondrial calcium ion homeostasis Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0


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