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Query: DDX41

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DDX41 0 -0.576 -0.480 0.420 -0.511 0.271
DDX41 0 -0.576 -0.480 0.420 -0.358 -0.293 0.363

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DDX41 Phosphorylation S23 -0.290 -0.637 _S(ph)EAEDEDDEDYVPYVPLR_
DDX41 Phosphorylation S21 -0.756 -0.696 _TDEVPAGGS(ph)RSEAEDEDDEDYVPYVPLR_
DDX41 Ubiquitylation K130 0.459 _ALMSVK(gl)EMAK_

Background Information for DDX41:


Pubmed-DDX41 »
Uniprot-DDX41 »
Biogrid-DDX41 »
ProteomicsDB-DDX41 »

Tumorportal-DDX41 »
COSMIC-DDX41 »
GenomeRNAi-DDX41 »
Genecards-DDX41


Protein-protein Interactions for DDX41
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CSDE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DVL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TBC1D9 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS41 Cat. description Hein, Mann, Cell 2015
Category members IP bait CSNK2A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NKAP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DDX41
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Znf_CCHC IPR001878 1.51
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members RNA_helicase_DEAD_Q_motif IPR014014 0.24


Protein complexes (CORUM database) featuring DDX41
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39


Categories featuring DDX41
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0032479 regulation of type I interferon production Database 0.04
Category members GO Category GO:0035458 cellular response to interferon-beta Database 0


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