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Query: DCTN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DCTN2 0 1.313 0.200 -0.010
DCTN2 0 1.313 0.200 -0.010 -0.205

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DCTN2 Ubiquitylation K70 0.861 0.880 _VGTK(gl)GLDFSDR_
DCTN2 Ubiquitylation K294 0.417 _LQSVLGK(gl)VNEIAK_
DCTN2 Phosphorylation T198 -0.227 0.004 _TTGT(ph)PPDSSLVTYELHSRPEQDK_
DCTN2 Ubiquitylation K234 -0.575 _VAELEK(gl)R_
DCTN2 Ubiquitylation K130 0.152 _TTVK(gl)ESATEEK_
DCTN2 Ubiquitylation K180 -1.718 _LLGPDAAINLTDPDGALAK(gl)R_

Background Information for DCTN2:





Protein-protein Interactions for DCTN2

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR1B Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN4 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNC1H1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNC1LI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLRB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait C1orf106 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAPZA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSPP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCTN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCTN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCTN6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFB127 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MIS18A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIC8A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS19BP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UQCRH Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DCTN2

Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring DCTN2

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DCTN2

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members GO Category GO:0007052 mitotic spindle organization Database 0.41
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0007017 microtubule-based process Database 0.3
Category members GO Category GO:0030286 dynein complex Database 0.27
Category members GO Category GO:0003774 motor activity Database 0.2
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0031982 vesicle Database 0.01
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members GO Category GO:0005869 dynactin complex Database 0


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