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Query: CUL5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CUL5 0 1.157 0.290 -0.440 -0.390 0.300 -0.122

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CUL5 Ubiquitylation K724 1.320 0.050 _TQEAIIQIMK(gl)MR_
CUL5 Ubiquitylation K727 -0.081 _TQEAIIQIM(ox)K(gl)M(ox)RK_
CUL5 Ubiquitylation K8 0.188 _(ac)ATSNLLK(gl)NK_
CUL5 Ubiquitylation K397 -0.357 _GVGLK(gl)TQPESK_

Background Information for CUL5:


Pubmed-CUL5 »
Uniprot-CUL5 »
Biogrid-CUL5 »
ProteomicsDB-CUL5 »

Tumorportal-CUL5 »
COSMIC-CUL5 »
GenomeRNAi-CUL5 »
Genecards-CUL5


Protein-protein Interactions for CUL5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ASB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CISH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CUL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NOSIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB40A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB40AL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB40B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOCS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOCS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPSB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WSB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CUL5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cullin_homology IPR016158 1.15
Category members Cullin_N IPR001373 0.9
Category members Cullin_neddylation_domain IPR019559 0.68
Category members Cullin_repeat-like_dom IPR016159 0.66


Protein complexes (CORUM database) featuring CUL5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 207 Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 208 Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 209 Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 210 Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 211 Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 214 Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1) Database 0


Categories featuring CUL5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_796 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G 0 1.14
Category members GO Category GO:0031461 cullin-RING ubiquitin ligase complex Database 0.77
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0070588 calcium ion transmembrane transport Database 0.25
Category members GO Category GO:0005262 calcium channel activity Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0006970 response to osmotic stress Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0031466 Cul5-RING ubiquitin ligase complex Database 0
Category members GO Category GO:0051480 cytosolic calcium ion homeostasis Database 0


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