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Query: CUL4B

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CUL4B 2 10.518 1.400 -0.970 0.667 2.694 2.782 0.664 0.727

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CUL4B Ubiquitylation K403 1.248 0.711 _LYAAEGQK(gl)LMQER_
CUL4B Ubiquitylation K789 -0.602 0.356 _TLQSLACGK(gl)AR_
CUL4B Phosphorylation T49 0.078 0.263 _SATDGNTSTT(ph)PPTSAK_
CUL4B Phosphorylation S53 -0.213 _SATDGNTSTT(ph)PPTS(ph)AK_
CUL4B Phosphorylation T52 -1.359 _SATDGNTSTT(ph)PPT(ph)SAK_
CUL4B Phosphorylation S146 0.762 _MAEESSSSSSSSS(ph)PTAATSQQQQLK_
CUL4B Ubiquitylation K258 0.200 _ISANLYK(gl)QLR_
CUL4B Ubiquitylation K341 0.655 _AHIISDQK(gl)VQNK_
CUL4B Ubiquitylation K609 0.798 _DVFEAFYKK(gl)_

Background Information for CUL4B:


Pubmed-CUL4B »
Uniprot-CUL4B »
Biogrid-CUL4B »
ProteomicsDB-CUL4B »

Tumorportal-CUL4B »
COSMIC-CUL4B »
GenomeRNAi-CUL4B »
Genecards-CUL4B


Protein-protein Interactions for CUL4B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BRWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait COPS7A Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4B Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait C4orf6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS7B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRBN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRYBA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF12L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DET1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GCNT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLMN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMCO3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRPC4AP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDTC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CUL4B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cullin_homology IPR016158 1.15
Category members Cullin_N IPR001373 0.9
Category members Cullin_neddylation_domain IPR019559 0.68
Category members Cullin_repeat-like_dom IPR016159 0.66


Protein complexes (CORUM database) featuring CUL4B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1162 Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) Database 0.91
Category members Corum 224 CAND1-CUL4B-RBX1 complex Database 0.06
Category members Corum 1211 Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) Database 0.05


Categories featuring CUL4B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0031461 cullin-RING ubiquitin ligase complex Database 0.77
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0031465 Cul4B-RING ubiquitin ligase complex Database 0.04
Category members GO Category GO:0045732 positive regulation of protein catabolic process Database 0


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