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Query: CRBN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CRBN 0 0.223 0.460 -0.110

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CRBN Ubiquitylation K300 -0.793 0.781 _IQLLK(gl)IGSAIQR_
CRBN Ubiquitylation K116 -0.048 0.253 _NLIQK(gl)DR_
CRBN Phosphorylation S25 -0.511 _(ac)AGEGDQQDAAHNMGNHLPLLPAES(ph)EEEDEMEVEDQDSK_
CRBN Ubiquitylation K166 -0.610 _FK(gl)VLELR_

Background Information for CRBN:


Pubmed-CRBN »
Uniprot-CRBN »
Biogrid-CRBN »
ProteomicsDB-CRBN »

Tumorportal-CRBN »
COSMIC-CRBN »
GenomeRNAi-CRBN »
Genecards-CRBN


Protein-protein Interactions for CRBN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CFP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRBN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLMN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KHDRBS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTRF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGIF2LY Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CRBN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Pept_S16_N IPR003111 0
Category members PUA-like_domain IPR015947 0


Protein complexes (CORUM database) featuring CRBN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CRBN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0032463 negative regulation of protein homooligomerization Database 0.11
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0031464 Cul4A-RING ubiquitin ligase complex Database 0.04
Category members Disease phenotype Distal_monosomy_3p Distal monosomy 3p Database 0.04
Category members Disease phenotype Autosomal_recessive_non-syndromic_intellectual_disability Autosomal recessive non-syndromic intellectual disability Database 0
Category members GO Category GO:0004176 ATP-dependent peptidase activity Database 0
Category members GO Category GO:0006508 proteolysis Database 0


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