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bioLOGIC Data

Query: CHRNA5

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
CHRNA5	0	-2.306	0.230	-0.710

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
CHRNA5	Ubiquitylation	K377	-2.137	-0.169	_YFTQK(gl)EETESGSGPK_
CHRNA5	Ubiquitylation	K387		-0.305	_YFTQKEETESGSGPK(gl)SSR_
CHRNA5	Ubiquitylation	K149		-0.444	_FEGTSTK(gl)TVIR_
CHRNA5	Ubiquitylation	K119		-0.682	_WNPDDYGGIK(gl)VIR_

Background Information for CHRNA5:

Pubmed-CHRNA5 »

Uniprot-CHRNA5 »

Biogrid-CHRNA5 »

ProteomicsDB-CHRNA5 »

Tumorportal-CHRNA5 »

COSMIC-CHRNA5 »

GenomeRNAi-CHRNA5 »

Genecards-CHRNA5

Protein-protein Interactions for CHRNA5

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait DEFA1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait GPR114	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SLAMF1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait TMEM30A	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in CHRNA5

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	Neurotrans-gated_channel_TM	IPR006029	0.09
Category members	Neur_chan_lig-bd	IPR006202	0.09
Category members	Neur_channel	IPR006201	0.08
Category members	Nicotinic_acetylcholine_rcpt	IPR002394	0

Protein complexes (CORUM database) featuring CHRNA5

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)

Categories featuring CHRNA5

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0016021	integral to membrane	Database	7.67
Category members	Pathway	Pathway_1184	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	0	1.89
Category members	GO Category	GO:0005886	plasma membrane	Database	1.21
Category members	GO Category	GO:0016020	membrane	Database	0.52
Category members	GO Category	GO:0007268	synaptic transmission	Database	0.23
Category members	GO Category	GO:0006811	ion transport	Database	0.18
Category members	GO Category	GO:0045211	postsynaptic membrane	Database	0.06
Category members	GO Category	GO:0005230	extracellular ligand-gated ion channel activity	Database	0
Category members	Pathway	Pathway_1191	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	0	0
Category members	Pathway	Pathway_1192	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	0	0
Category members	Pathway	Pathway_1238	REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	0	0
Category members	Pathway	Pathway_139	REACTOME_NEURONAL_SYSTEM	0	0
Category members	Pathway	Pathway_140	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	0	0
Category members	Pathway	Pathway_230	REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL	0	0
Category members	Disease phenotype	SMOKING_AS_A_QUANTITATIVE_TRAIT_LOCUS_3	SMOKING AS A QUANTITATIVE TRAIT LOCUS 3	Database	0
Category members	GO Category	GO:0004889	acetylcholine-activated cation-selective channel activity	Database	0
Category members	GO Category	GO:0005892	acetylcholine-gated channel complex	Database	0
Category members	GO Category	GO:0006810	transport	Database	0
Category members	GO Category	GO:0007165	signal transduction	Database	0
Category members	GO Category	GO:0015276	ligand-gated ion channel activity	Database	0
Category members	GO Category	GO:0015464	acetylcholine receptor activity	Database	0
Category members	GO Category	GO:0030054	cell junction	Database	0
Category members	GO Category	GO:0035094	response to nicotine	Database	0
Category members	GO Category	GO:0035095	behavioral response to nicotine	Database	0