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Query: CDCA8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDCA8 0 0.527
CDCA8 0 0.527 -0.883 -0.739

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDCA8 Phosphorylation S219 0.796 0.753 _IYNISGNGS(ph)PLADSK_
CDCA8 Ubiquitylation K37 0.600 _IK(gl)QIESDRQNLLK_
CDCA8 Ubiquitylation K183 -1.967 _LEVSMVK(gl)PTPGLTPR_

Background Information for CDCA8:


Pubmed-CDCA8 »
Uniprot-CDCA8 »
Biogrid-CDCA8 »
ProteomicsDB-CDCA8 »

Tumorportal-CDCA8 »
COSMIC-CDCA8 »
GenomeRNAi-CDCA8 »
Genecards-CDCA8


Protein-protein Interactions for CDCA8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDCA8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4B Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20A Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF2C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NFYC Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP9 Cat. description Hein, Mann, Cell 2015
Category members IP bait BIRC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDCA8
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring CDCA8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2582 Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5) Database 0.05
Category members Corum 1118 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) Database 0
Category members Corum 1119 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) Database 0
Category members Corum 1120 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) Database 0


Categories featuring CDCA8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0032133 chromosome passenger complex Database 0.29
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members GO Category GO:0005825 half bridge of spindle pole body Database 0.04
Category members GO Category GO:0000089 mitotic metaphase Database 0
Category members GO Category GO:0010369 chromocenter Database 0


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