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Query: CDC27

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDC27 1 5.273 0.150 -0.590 0.507 1.052 0.322 0.135
CDC27 1 5.273 0.150 -0.590 0.262 0.221 1.276 0.303 0.326

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDC27 Phosphorylation S432 3.398 _GGITQPNINDS(ph)LEITK_
CDC27 Ubiquitylation K726 -0.818 _ASVLFANEKYK(gl)_

Background Information for CDC27:


Pubmed-CDC27 »
Uniprot-CDC27 »
Biogrid-CDC27 »
ProteomicsDB-CDC27 »

Tumorportal-CDC27 »
COSMIC-CDC27 »
GenomeRNAi-CDC27 »
Genecards-CDC27


Protein-protein Interactions for CDC27
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC13 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC15 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1B Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC20 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHD8 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1430 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5B Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF526 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANO6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BUB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf87 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCLRE1C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FDPS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIF2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGIX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PENK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF19B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RSBN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3KBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRP68 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTLL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF408 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDC27
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TPR_1 IPR001440 1.39
Category members TPR-contain_dom IPR013026 0.97
Category members TPR_repeat IPR019734 0.93
Category members TPR_2 IPR013105 0.45


Protein complexes (CORUM database) featuring CDC27
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 93 Anaphase-promoting complex Database 3.53
Category members Corum 96 Anaphase-promoting complex Database 2.83
Category members Corum 5361 Cell division cycle complex (CDC27, CDC16, ANAPC7) Database 0.65


Categories featuring CDC27
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.38
Category members GO Category GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.35
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members Pathway Pathway_827 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C 0 3.01
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members Pathway Pathway_780 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 0 2.46
Category members Pathway Pathway_784 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 0 2.26
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members Pathway Pathway_836 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A 0 1.58
Category members GO Category GO:0007091 metaphase/anaphase transition of mitotic cell cycle Database 1.58
Category members Pathway Pathway_818 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B 0 1.37
Category members GO Category GO:0051301 cell division Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_1247 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE 0 1.09
Category members Pathway Pathway_1245 REACTOME_PHOSPHORYLATION_OF_THE_APC_C 0 1.06
Category members Pathway Pathway_1246 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS 0 0.98
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0005876 spindle microtubule Database 0.68
Category members GO Category GO:0007094 mitotic spindle assembly checkpoint Database 0.68
Category members GO Category GO:0005680 anaphase-promoting complex Database 0.63
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0070979 protein K11-linked ubiquitination Database 0.25
Category members GO Category GO:0008283 cell proliferation Database 0.06


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