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Query: CASC3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CASC3 0 -0.144 1.440 -1.030

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CASC3 Phosphorylation S148 0.609 0.451 _STVTGERQS(ph)GDGQESTEPVENK_
CASC3 Phosphorylation S265 -0.457 -0.532 _YGS(ph)PPQR_
CASC3 Ubiquitylation K205 -2.945 _GQTQEEEVRPK(gl)GR_
CASC3 Ubiquitylation K254 -1.517 _SAHNPDDIK(gl)PR_
CASC3 Ubiquitylation K344 -1.204 _SGETVK(gl)HEISYR_

Background Information for CASC3:


Pubmed-CASC3 »
Uniprot-CASC3 »
Biogrid-CASC3 »
ProteomicsDB-CASC3 »

Tumorportal-CASC3 »
COSMIC-CASC3 »
GenomeRNAi-CASC3 »
Genecards-CASC3


Protein-protein Interactions for CASC3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CHST15 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2E2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KDM1B Cat. description Hein, Mann, Cell 2015
Category members IP bait LLGL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MED12 Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM8A Cat. description Hein, Mann, Cell 2015
Category members IP bait UPF3B Cat. description Hein, Mann, Cell 2015
Category members IP bait APOBEC3D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C11orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ELAVL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GSPT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUC7L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUC7L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGOH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRDM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRA2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait U2AF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UPF3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTI1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WIBG Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CASC3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Btz_dom IPR018545 0


Protein complexes (CORUM database) featuring CASC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 740 Exon junction complex, EIF4A3-MLN51-MAGOH-Y14 (RNA-protein complex) Database 0
Category members Corum 744 Exon junction complex (EIF4A3-MLN51-MAGOH-Y14) Database 0
Category members Corum 754 Exon junction complex (EIF4A3-MLN51-UPF3B-MAGOH-Y14) Database 0
Category members Corum 755 Exon junction complex (F4A3-MLN51-UPF3B-MAGOH-Y14-PYM) Database 0
Category members Corum 769 Exon junction complex (EIF4A3-MLN51-MAGOH-Y14), RNA-protein complex Database 0
Category members Corum 772 eIF4AIII-Btz complex Database 0


Categories featuring CASC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_770 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0051028 mRNA transport Database 1.7
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0035145 exon-exon junction complex Database 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0008150 biological_process Database 0
Category members GO Category GO:0008298 intracellular mRNA localization Database 0


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