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Query: CARS

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CARS 0 1.278 -0.880 0.880 0.696 -0.132 -0.166

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for CARS:


Pubmed-CARS »
Uniprot-CARS »
Biogrid-CARS »
ProteomicsDB-CARS »

Tumorportal-CARS »
COSMIC-CARS »
GenomeRNAi-CARS »
Genecards-CARS


Protein-protein Interactions for CARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EEF1A1;EEF1A1P5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ABTB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BATF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LITAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLLT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Glutathione-S-Trfase_C-like IPR010987 0.23
Category members tRNAsynth_1a_anticodon-bd IPR009080 0
Category members Methionyl/Leucyl_tRNA_Synth IPR015413 0
Category members Cys-tRNA-ligase IPR015803 0
Category members Cys-tRNA/MSH_ligase IPR024909 0


Protein complexes (CORUM database) featuring CARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0004812 aminoacyl-tRNA ligase activity Database 0.41
Category members Disease phenotype Inflammatory_myofibroblastic_tumor Inflammatory myofibroblastic tumor Database 0.23
Category members GO Category GO:0000049 tRNA binding Database 0
Category members GO Category GO:0004817 cysteine-tRNA ligase activity Database 0
Category members GO Category GO:0006423 cysteinyl-tRNA aminoacylation Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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