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Query: CAP2

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CAP2 0 -1.352 0.850 -0.440

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CAP2 Phosphorylation S312 -0.663 -0.689 _SHTPSPTS(ph)PK_

Background Information for CAP2:


Pubmed-CAP2 »
Uniprot-CAP2 »
Biogrid-CAP2 »
ProteomicsDB-CAP2 »

Tumorportal-CAP2 »
COSMIC-CAP2 »
GenomeRNAi-CAP2 »
Genecards-CAP2


Protein-protein Interactions for CAP2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CFL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TWF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CAP2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Adenylate_cyclase-assoc_CAP_C IPR013912 0.17
Category members CARP_motif IPR006599 0.13
Category members Tubulin-bd_cofactor_C_dom IPR012945 0.05
Category members Adenylate_cyclase-assoc_CAP_N IPR013992 0


Protein complexes (CORUM database) featuring CAP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CAP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1031 REACTOME_SIGNALING_BY_ROBO_RECEPTOR 0 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0007010 cytoskeleton organization Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007190 activation of adenylate cyclase activity Database 0


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