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Query: BUB3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BUB3 0 -0.112 1.300 -0.710 -0.089 0.300 0.601 -0.954 -0.333

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BUB3 Ubiquitylation K179 0.382 -0.019 _RESSLK(gl)YQTR_
BUB3 Ubiquitylation K139 -0.810 -0.259 _TPCNAGTFSQPEK(gl)VYTLSVSGDR_
BUB3 Ubiquitylation K216 -0.270 _VAVEYLDPSPEVQK(gl)K_
BUB3 Ubiquitylation K322 -0.687 -0.496 _QVTDAETK(gl)PK_
BUB3 Ubiquitylation K217 -0.808 -0.573 _VAVEYLDPSPEVQKK(gl)_
BUB3 Ubiquitylation K191 -0.888 -0.645 _AFPNK(gl)QGYVLSSIEGR_
BUB3 Ubiquitylation K8 -0.663 -1.612 _TGSNEFK(gl)LNQPPEDGISSVK_
BUB3 Ubiquitylation K218 -1.484 _VAVEYLDPSPEVQKKK(gl)_

Background Information for BUB3:


Pubmed-BUB3 »
Uniprot-BUB3 »
Biogrid-BUB3 »
ProteomicsDB-BUB3 »

Tumorportal-BUB3 »
COSMIC-BUB3 »
GenomeRNAi-BUB3 »
Genecards-BUB3


Protein-protein Interactions for BUB3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BUB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1B Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC20 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNPS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZFC3H1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCT7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BUB3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12


Protein complexes (CORUM database) featuring BUB3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1851 BUB1-BUB3 complex Database 0
Category members Corum 190 Mitotic checkpoint complex (MCC) Database 0


Categories featuring BUB3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.35
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members Pathway Pathway_784 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 0 2.26
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_836 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A 0 1.58
Category members Pathway Pathway_1246 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS 0 0.98
Category members GO Category GO:0007094 mitotic spindle assembly checkpoint Database 0.68
Category members GO Category GO:0000777 condensed chromosome kinetochore Database 0.32
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0007126 meiosis Database 0.01
Category members Disease phenotype Mosaic_variegated_aneuploidy_syndrome Mosaic variegated aneuploidy syndrome Database 0
Category members GO Category GO:0000070 mitotic sister chromatid segregation Database 0
Category members GO Category GO:0008608 attachment of spindle microtubules to kinetochore Database 0
Category members GO Category GO:0051983 regulation of chromosome segregation Database 0
Category members GO Category GO:0071173 spindle assembly checkpoint Database 0


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