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Query: BRD3

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BRD3 0 0.092 -0.570 0.450 0.293 0.252

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BRD3 Phosphorylation S263 -0.787 -0.714 _SES(ph)PPPLSDPK_
BRD3 Phosphorylation T249 -0.461 _ADTT(ph)TPTTSAITASR_
BRD3 Phosphorylation T250 -0.189 _ADTTT(ph)PTTSAITASR_

Background Information for BRD3:


Pubmed-BRD3 »
Uniprot-BRD3 »
Biogrid-BRD3 »
ProteomicsDB-BRD3 »

Tumorportal-BRD3 »
COSMIC-BRD3 »
GenomeRNAi-BRD3 »
Genecards-BRD3


Protein-protein Interactions for BRD3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CASC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait NFYC Cat. description Hein, Mann, Cell 2015
Category members IP bait TACC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BRD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMKV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM90A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BRD3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Bromodomain IPR001487 1.43


Protein complexes (CORUM database) featuring BRD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring BRD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0070577 histone acetyl-lysine binding Database 0.88
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0016568 chromatin modification Database 0.18


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