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Query: BCLAF1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BCLAF1 2 9.702 -0.180 -0.380
BCLAF1 2 9.702 -0.180 -0.380 -0.950 0.737
BCLAF1 2 9.702 -0.180 -0.380 0.934 -1.060 0.494 0.092 0.058

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BCLAF1 Phosphorylation T341 4.144 4.415 _RFT(ph)DEESR_
BCLAF1 Phosphorylation S183 2.654 2.903 _S(ph)QEEPKDTFEHDPSESIDEFNK_
BCLAF1 Phosphorylation T190 2.752 _SKSQEEPKDT(ph)FEHDPSESIDEFNK_
BCLAF1 Phosphorylation S385 0.879 0.910 _GRAEGEWEDQEALDYFS(ph)DKESGK_
BCLAF1 Phosphorylation Y284 1.169 0.845 _Y(ph)SPSQNSPIHHIPSR_
BCLAF1 Phosphorylation T402 0.754 0.839 _FNDS(ph)EGDDT(ph)EETEDYR_
BCLAF1 Phosphorylation S287 -0.086 0.781 _YS(ph)PS(ph)QNSPIHHIPSR_
BCLAF1 Phosphorylation S285 0.787 0.744 _Y(ph)S(ph)PSQNSPIHHIPSR_
BCLAF1 Phosphorylation T494 0.602 0.680 _ET(ph)QSPEQVKSEK_
BCLAF1 Phosphorylation S397 0.646 0.646 _FNDS(ph)EGDDTEETEDYR_
BCLAF1 Phosphorylation S496 0.626 0.617 _KETQS(ph)PEQVK_
BCLAF1 Phosphorylation S658 0.315 0.496 _IDIS(ph)PSTLRK_
BCLAF1 Phosphorylation S531 0.421 0.441 _STFREES(ph)PLR_
BCLAF1 Phosphorylation S337 0.343 _FLKS(ph)PPLHK_
BCLAF1 Phosphorylation S648 0.580 0.332 _QKS(ph)PEIHR_
BCLAF1 Phosphorylation S512 0.225 0.163 _LKDLFDYS(ph)PPLHK_
BCLAF1 Phosphorylation S222 -0.154 -0.066 _SSATSGDIWPGLSAYDNS(ph)PR_
BCLAF1 Phosphorylation S268 -0.125 _NTPSQHSHSIQHS(ph)PER_
BCLAF1 Phosphorylation S290 -0.774 -0.519 _YS(ph)PSQNS(ph)PIHHIPSR_
BCLAF1 Phosphorylation S177 -0.516 -0.561 _KAEGEPQEES(ph)PLK_
BCLAF1 Phosphorylation S181 -0.748 -0.602 _KAEGEPQEESPLKS(ph)K_
BCLAF1 Phosphorylation S196 -0.833 _SQEEPKDTFEHDPS(ph)ESIDEFNK_
BCLAF1 Phosphorylation S198 -1.164 _SQEEPKDTFEHDPSES(ph)IDEFNK_
BCLAF1 Phosphorylation T566 -1.236 _MAPVPLDDSNRPASLT(ph)K_
BCLAF1 Phosphorylation T840 -1.185 -1.707 _EEEWDPEYT(ph)PK_
BCLAF1 Ubiquitylation K332 -0.379 _SSFYPDGGDQETAK(gl)TGK_
BCLAF1 Phosphorylation Y383 0.945 _AEGEWEDQEALDY(ph)FSDKESGK_
BCLAF1 Ubiquitylation K437 0.272 _NTEEEGLK(gl)YK_
BCLAF1 Phosphorylation Y511 0.005 _DLFDY(ph)SPPLHK_
BCLAF1 Ubiquitylation K567 -0.584 _MAPVPLDDSNRPASLTK(gl)DR_
BCLAF1 Ubiquitylation K637 -0.057 _FTSYQK(gl)ATEEHSTR_
BCLAF1 Phosphorylation S660 0.662 _RIDISPS(ph)TLR_

Background Information for BCLAF1:


Pubmed-BCLAF1 »
Uniprot-BCLAF1 »
Biogrid-BCLAF1 »
ProteomicsDB-BCLAF1 »

Tumorportal-BCLAF1 »
COSMIC-BCLAF1 »
GenomeRNAi-BCLAF1 »
Genecards-BCLAF1


Protein-protein Interactions for BCLAF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCLAF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKN2AIPNL Cat. description Hein, Mann, Cell 2015
Category members IP bait DENND6A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH7B Cat. description Hein, Mann, Cell 2015
Category members IP bait PDGFRB Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMB5 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CORO2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUC7L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUC7L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRMT8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait U2AF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BCLAF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Btz_dom IPR018545 0


Protein complexes (CORUM database) featuring BCLAF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring BCLAF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0043620 regulation of DNA-dependent transcription in response to stress Database 0


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