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Query: BCL11B

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BCL11B 0 -0.855 -0.600 -0.050 -0.645 -0.251

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BCL11B Phosphorylation S97 0.399 -0.308 _ALDKDS(ph)PPPSSR_
BCL11B Phosphorylation T754 0.033 -0.354 _FST(ph)PPGDLLDGGLSGR_
BCL11B Phosphorylation T376 -0.644 -1.439 _ELAGNSST(ph)PPPVS(ph)PGR_
BCL11B Phosphorylation S381 -0.644 -1.439 _ELAGNSST(ph)PPPVS(ph)PGR_
BCL11B Phosphorylation S129 -0.095 _VSEPVEIGIQVTPDEDDHLLS(ph)PTK_
BCL11B Phosphorylation T131 -0.689 _VSEPVEIGIQVTPDEDDHLLSPT(ph)K_

Background Information for BCL11B:


Pubmed-BCL11B »
Uniprot-BCL11B »
Biogrid-BCL11B »
ProteomicsDB-BCL11B »

Tumorportal-BCL11B »
COSMIC-BCL11B »
GenomeRNAi-BCL11B »
Genecards-BCL11B


Protein-protein Interactions for BCL11B
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in BCL11B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92


Protein complexes (CORUM database) featuring BCL11B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring BCL11B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0003334 keratinocyte development Database 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0021953 central nervous system neuron differentiation Database 0.06
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0003382 epithelial cell morphogenesis Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010837 regulation of keratinocyte proliferation Database 0
Category members GO Category GO:0019216 regulation of lipid metabolic process Database 0
Category members GO Category GO:0031077 post-embryonic camera-type eye development Database 0
Category members GO Category GO:0033153 T cell receptor V(D)J recombination Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0043368 positive T cell selection Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0045664 regulation of neuron differentiation Database 0
Category members GO Category GO:0046632 alpha-beta T cell differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048538 thymus development Database 0


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