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Query: ATXN3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ATXN3 0 3.698 -1.590 2.440

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ATXN3 Ubiquitylation K200 0.446 0.812 _LIGEELAQLK(gl)EQR_
ATXN3 Ubiquitylation K206 0.142 0.741 _VHK(gl)TDLER_
ATXN3 Ubiquitylation K291 0.025 0.575 _EAYFEK(gl)QQQK_
ATXN3 Ubiquitylation K190 -0.322 _VQQM(ox)HRPK(gl)LIGEELAQLK_

Background Information for ATXN3:


Pubmed-ATXN3 »
Uniprot-ATXN3 »
Biogrid-ATXN3 »
ProteomicsDB-ATXN3 »

Tumorportal-ATXN3 »
COSMIC-ATXN3 »
GenomeRNAi-ATXN3 »
Genecards-ATXN3


Protein-protein Interactions for ATXN3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AFF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATXN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP152 Cat. description Hein, Mann, Cell 2015
Category members IP bait NFKBIA Cat. description Hein, Mann, Cell 2015
Category members IP bait PAFAH1B1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AEBP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DND1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOMM20L Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ATXN3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-int_motif IPR003903 0.49
Category members Josephin IPR006155 0


Protein complexes (CORUM database) featuring ATXN3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ATXN3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0004221 ubiquitin thiolesterase activity Database 1.36
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042405 nuclear inclusion body Database 0.82
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0035520 monoubiquitinated protein deubiquitination Database 0.54
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members GO Category GO:0008242 omega peptidase activity Database 0.28
Category members GO Category GO:0001012 RNA polymerase II regulatory region DNA binding Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0034605 cellular response to heat Database 0.18
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0006515 misfolded or incompletely synthesized protein catabolic process Database 0.04
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0031966 mitochondrial membrane Database 0
Category members GO Category GO:0035640 exploration behavior Database 0
Category members GO Category GO:0045104 intermediate filament cytoskeleton organization Database 0
Category members GO Category GO:0070932 histone H3 deacetylation Database 0
Category members GO Category GO:0071218 cellular response to misfolded protein Database 0


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