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Query: ASXL1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ASXL1 0 0.614 -0.670 0.740 -1.339

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ASXL1 Ubiquitylation K351 0.813 0.619 _KVEQWK(gl)EK_
ASXL1 Ubiquitylation K353 0.339 _KVEQWK(gl)EK_
ASXL1 Phosphorylation S503 -0.013 -0.206 _ASAS(ph)PDRIPSLPQETVDQEPK_
ASXL1 Phosphorylation S501 -0.370 _AS(ph)ASPDRIPSLPQETVDQEPK_

Background Information for ASXL1:


Pubmed-ASXL1 »
Uniprot-ASXL1 »
Biogrid-ASXL1 »
ProteomicsDB-ASXL1 »

Tumorportal-ASXL1 »
COSMIC-ASXL1 »
GenomeRNAi-ASXL1 »
Genecards-ASXL1


Protein-protein Interactions for ASXL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAP1 Cat. description Hein, Mann, Cell 2015


Protein Domains in ASXL1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring ASXL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ASXL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0045599 negative regulation of fat cell differentiation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0042975 peroxisome proliferator activated receptor binding Database 0.05
Category members GO Category GO:0035522 monoubiquitinated histone H2A deubiquitination Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0042974 retinoic acid receptor binding Database 0.02
Category members GO Category GO:0048387 negative regulation of retinoic acid receptor signaling pathway Database 0.01
Category members Disease phenotype MYELODYSPLASTIC_SYNDROME MYELODYSPLASTIC SYNDROME Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0032526 response to retinoic acid Database 0
Category members GO Category GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048386 positive regulation of retinoic acid receptor signaling pathway Database 0
Category members GO Category GO:0060348 bone development Database 0


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