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Query: ASCC3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ASCC3 6 19.495 -2.500 4.400 1.365 -0.715 -0.792 0.712 0.535
ASCC3 6 19.495 2.300 -1.140 1.365 -0.715 -0.792 0.712 0.535

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ASCC3 Phosphorylation S2195 2.989 2.370 _VSDS(ph)LTDLALK_
ASCC3 Ubiquitylation K197 4.182 1.860 _TISLDYK(gl)K_
ASCC3 Ubiquitylation K198 4.471 1.560 _TISLDYKK(gl)_
ASCC3 Ubiquitylation K312 2.919 0.713 _FQALQDNCKK(gl)_
ASCC3 Ubiquitylation K311 2.994 0.702 _FQALQDNCK(gl)K_
ASCC3 Ubiquitylation K572 0.464 _ELTGDMQLSK(gl)SEILR_
ASCC3 Ubiquitylation K1543 -0.021 _MASMNK(gl)PAFQAIR_
ASCC3 Ubiquitylation K1369 -0.219 _VFNK(gl)YPTSK_
ASCC3 Ubiquitylation K1671 1.280 -0.224 _GTEYYDGK(gl)TR_
ASCC3 Ubiquitylation K1382 -1.028 _AVYIAPLK(gl)ALVR_
ASCC3 Ubiquitylation K1416 -1.216 _VIELTGDVTPDMK(gl)SIAK_
ASCC3 Ubiquitylation K2097 1.163 _GK(gl)PESCAVTPR_

Background Information for ASCC3:


Pubmed-ASCC3 »
Uniprot-ASCC3 »
Biogrid-ASCC3 »
ProteomicsDB-ASCC3 »

Tumorportal-ASCC3 »
COSMIC-ASCC3 »
GenomeRNAi-ASCC3 »
Genecards-ASCC3


Protein-protein Interactions for ASCC3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALKBH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASCC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THBS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF263 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ASCC3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Sec63-dom IPR004179 0.85
Category members Helicase/UvrB_dom IPR006935 0.78
Category members AAA+_ATPase IPR003593 0.38
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35


Protein complexes (CORUM database) featuring ASCC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1377 hASC-1 complex Database 0.47


Categories featuring ASCC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0043140 ATP-dependent 3'-5' DNA helicase activity Database 0.25
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Disease phenotype Autosomal_Recessive_Mental_Retardation Autosomal Recessive Mental Retardation Database 0
Category members GO Category GO:0006307 DNA dealkylation involved in DNA repair Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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