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Query: ANK3

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ANK3 0 3.289 0.110 -0.340
ANK3 0 3.289 0.110 -0.340 -0.060 1.268 0.717

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ANK3 Phosphorylation S4298 0.236 0.621 _IHGSGHVEEPAS(ph)PLAAYQK_
ANK3 Phosphorylation S1405 0.434 0.363 _IRDTS(ph)QEPCGR_
ANK3 Phosphorylation S1462 0.189 _RYS(ph)YLTEPGMSPQSPCER_
ANK3 Phosphorylation S1459 0.743 0.188 _RQS(ph)FASLALR_

Background Information for ANK3:


Pubmed-ANK3 »
Uniprot-ANK3 »
Biogrid-ANK3 »
ProteomicsDB-ANK3 »

Tumorportal-ANK3 »
COSMIC-ANK3 »
GenomeRNAi-ANK3 »
Genecards-ANK3


Protein-protein Interactions for ANK3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CRY1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DENND6A Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF11 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGAP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C10orf47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DOK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FEZ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIF1AN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LILRB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK8IP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PALM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PWP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAPGEF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ANK3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DEATH-like_dom IPR011029 1.15
Category members Death_domain IPR000488 0.08
Category members ZU5_dom IPR000906 0
Category members Ankyrin_rpt IPR002110 0
Category members Ankyrin_rpt-contain_dom IPR020683 0


Protein complexes (CORUM database) featuring ANK3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ANK3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0043034 costamere Database 1.42
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0030507 spectrin binding Database 1.12
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0000281 mitotic cytokinesis Database 0.77
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0043001 Golgi to plasma membrane protein transport Database 0.32
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0045296 cadherin binding Database 0.26
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0045184 establishment of protein localization Database 0.1
Category members GO Category GO:0050808 synapse organization Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0043266 regulation of potassium ion transport Database 0.08
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_1287 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS 0 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0007009 plasma membrane organization Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007528 neuromuscular junction development Database 0
Category members GO Category GO:0009925 basal plasma membrane Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010765 positive regulation of sodium ion transport Database 0
Category members GO Category GO:0014731 spectrin-associated cytoskeleton Database 0
Category members GO Category GO:0016529 sarcoplasmic reticulum Database 0
Category members GO Category GO:0019228 regulation of action potential in neuron Database 0
Category members GO Category GO:0030315 T-tubule Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0033268 node of Ranvier Database 0
Category members GO Category GO:0033270 paranode region of axon Database 0
Category members GO Category GO:0034112 positive regulation of homotypic cell-cell adhesion Database 0
Category members GO Category GO:0043194 axon initial segment Database 0
Category members GO Category GO:0045838 positive regulation of membrane potential Database 0


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