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Query: AKR1B1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AKR1B1 1 3.920 1.548 0.831

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AKR1B1 Ubiquitylation K69 0.516 1.000 _LREQVVK(gl)R_
AKR1B1 Ubiquitylation K263 -0.301 -0.233 _NLVVIPK(gl)SVTPER_
AKR1B1 Ubiquitylation K12 -0.133 _LLLNNGAK(gl)MPILGLGTWK_
AKR1B1 Ubiquitylation K243 0.541 _HNK(gl)TTAQVLIR_

Background Information for AKR1B1:


Pubmed-AKR1B1 »
Uniprot-AKR1B1 »
Biogrid-AKR1B1 »
ProteomicsDB-AKR1B1 »

Tumorportal-AKR1B1 »
COSMIC-AKR1B1 »
GenomeRNAi-AKR1B1 »
Genecards-AKR1B1


Protein-protein Interactions for AKR1B1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AKR1B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AKR1B1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Aldo/keto_reductase_subgr IPR020471 0
Category members NADP_OxRdtase_dom IPR023210 0


Protein complexes (CORUM database) featuring AKR1B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring AKR1B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members Pathway Pathway_16 KEGG_PYRUVATE_METABOLISM 0 1.34
Category members Pathway Pathway_71 KEGG_GLYCEROLIPID_METABOLISM 0 0.45
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006700 C21-steroid hormone biosynthetic process Database 0.21
Category members Pathway Pathway_58 KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 0 0.1
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members Pathway Pathway_64 KEGG_GALACTOSE_METABOLISM 0 0.04
Category members GO Category GO:0009055 electron carrier activity Database 0.02
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_62 KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS 0 0
Category members Pathway Pathway_69 REACTOME_STEROID_HORMONES 0 0
Category members Pathway Pathway_70 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D 0 0
Category members GO Category GO:0004032 alditol:NADP+ 1-oxidoreductase activity Database 0
Category members GO Category GO:0004033 aldo-keto reductase (NADP) activity Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0008202 steroid metabolic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0044597 daunorubicin metabolic process Database 0
Category members GO Category GO:0044598 doxorubicin metabolic process Database 0


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