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Query: AAAS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AAAS 1 3.457 -1.570 2.880
AAAS 1 3.457 -1.570 2.880 -0.236 0.242 0.183

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AAAS Ubiquitylation K52 0.079 0.309 _GQWINLPVLQLTK(gl)DPLK_
AAAS Ubiquitylation K418 -0.364 _LAVLMK(gl)GK(gl)PR_
AAAS Ubiquitylation K416 -0.747 _LAVLMK(gl)GK(gl)PR_
AAAS Ubiquitylation K425 -0.805 _VQDGK(gl)PVILLFR_
AAAS Ubiquitylation K56 -1.545 -0.959 _DPLK(gl)TPGR_
AAAS Ubiquitylation K189 -1.183 _VYNASSTIVPSLK(gl)HR_

Background Information for AAAS:


Pubmed-AAAS »
Uniprot-AAAS »
Biogrid-AAAS »
ProteomicsDB-AAAS »

Tumorportal-AAAS »
COSMIC-AAAS »
GenomeRNAi-AAAS »
Genecards-AAAS


Protein-protein Interactions for AAAS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KPNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP107 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP98 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEH1L Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2I Cat. description Hein, Mann, Cell 2015


Protein Domains in AAAS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52


Protein complexes (CORUM database) featuring AAAS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring AAAS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members Pathway Pathway_1310 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS 0 7.24
Category members Pathway Pathway_1311 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY 0 7.24
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members Pathway Pathway_1206 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS 0 6.87
Category members GO Category GO:0005643 nuclear pore Database 6.58
Category members Pathway Pathway_878 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 0 6.53
Category members Pathway Pathway_886 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT 0 5.93
Category members GO Category GO:0010827 regulation of glucose transport Database 5.83
Category members GO Category GO:0007077 mitotic nuclear envelope disassembly Database 5.8
Category members Pathway Pathway_120 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN 0 5.24
Category members Pathway Pathway_887 REACTOME_METABOLISM_OF_NON_CODING_RNA 0 4.38
Category members GO Category GO:0008645 hexose transport Database 4.15
Category members Pathway Pathway_98 REACTOME_GLUCOSE_TRANSPORT 0 3.58
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0015758 glucose transport Database 2.09
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members Pathway Pathway_96 REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 0 0.23
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0003674 molecular_function Database 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members Disease phenotype Triple_A_syndrome Triple A syndrome Database 0
Category members GO Category GO:0007612 learning Database 0
Category members GO Category GO:0009566 fertilization Database 0
Category members GO Category GO:0046822 regulation of nucleocytoplasmic transport Database 0


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