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Query: ZNF521

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ZNF521 0 -0.764 -0.450 0.650
ZNF521 0 -0.764 -0.450 0.650 0.165 0.215

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ZNF521 Phosphorylation S640 -0.993 -0.801 _ALS(ph)PLSPVAIEQTSLK_

Background Information for ZNF521:


Pubmed-ZNF521 »
Uniprot-ZNF521 »
Biogrid-ZNF521 »
ProteomicsDB-ZNF521 »

Tumorportal-ZNF521 »
COSMIC-ZNF521 »
GenomeRNAi-ZNF521 »
Genecards-ZNF521


Protein-protein Interactions for ZNF521
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBD3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF219 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ZNF521
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92


Protein complexes (CORUM database) featuring ZNF521
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ZNF521
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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